生长抑素联用丹参或乌司他丁治疗重症急性胰腺炎疗效观察

发布时间：2018-06-27 13:02

本文选题：重症急性胰腺炎 + 生长抑素　；参考：《重庆医学》2016年06期

【摘要】：目的探讨生长抑素联用丹参或乌司他丁治疗重症急性胰腺炎(SAP)的效果。方法将246例SAP患者分成4组:生长抑素组(A组);生长抑素联合丹参组(B组);生长抑素联合乌司他丁组(C组);生长抑素联合乌司他丁和丹参组(D组)。观察4组患者腹痛及腹胀症状消失时间、心率及呼吸恢复正常时间、血淀粉酶及血糖恢复正常时间、住院时间、总住院费用及有效率。结果患者腹痛及腹胀消失时间、心率及呼吸恢复正常时间、血淀粉酶及血糖恢复正常时间和住院时间最短为D组,其他依次为C、B、A组,4组比较差异有统计学意义(P0.05);A、B、C、D组总有效率分别为65.57%、77.42%、81.54%、89.66%,4组比较差异有统计学意义(P0.05);4组不良反应发生率比较,差异无统计学意义(P0.05)。结论生长抑素能有效治疗SAP,与乌司他丁或丹参联用能提高疗效,但乌司他丁的疗效优于丹参,乌司他丁与丹参联用能进一步提高疗效。
[Abstract]:Objective to investigate the effect of somatostatin or Ulinastatin in the treatment of severe acute pancreatitis (SAP). Methods 246 patients with SAP were divided into 4 groups: somatostatin group (group A), somatostatin combined with Salvia miltiorrhiza group (group B), somatostatin combined with ulinastatin group (group C), somatostatin combined with Ulinastatin and Salvia miltiorrhiza group (group D). The abdominal pain in 4 groups of patients was observed. The symptoms disappeared, heart rate and respiration recovered normal time, blood amylase and blood sugar recovered normal time, hospitalization time, total hospitalization expenses and efficiency. Results patients with abdominal pain and abdominal distention time, heart rate and respiration recovered normal time, blood amylase and blood glucose recovery time and hospitalization time were D, the others were C, B, A group, the 4 groups were statistically significant (P0.05); A, B, C, the total effective rate of group D was 65.57%, 77.42%, 81.54%, 89.66%, and 4 groups were statistically significant (P0.05); the 4 groups of adverse reactions were not statistically significant (P0.05). Conclusion somatostatin can effectively treat SAP, and the combination of ulinastatin or Salvia miltiorrhiza can improve the efficacy, But Ulinastatin is better than Salvia miltiorrhiza. Ulinastatin combined with Salvia miltiorrhiza can further improve the curative effect.
【作者单位】：萍乡市人民医院消化内科;
【基金】：国家自然科学基金资助项目(81360080)
【分类号】：R576

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