四联疗法治疗2型糖尿病合并幽门螺杆菌阳性消化性溃疡的临床研究

发布时间：2018-06-27 22:49

本文选题：四联疗法 + 幽门螺杆菌　；参考：《中国临床药理学杂志》2017年12期

【摘要】：目的观察四联疗法治疗2型糖尿病合并幽门螺杆菌阳性消化性溃疡的临床疗效。方法 176例Hp阳性消化性溃疡患者为对照组,122例2型糖尿病合并Hp阳性消化性溃疡患者为试验组。2组患者均予以口服雷贝拉唑10 mg qd+口服克拉霉素0.25 g bid+口服阿莫西林0.5 g bid+口服枸橼酸铋钾0.3 g qid。克拉霉素与阿莫西林只服用前10天,其余药均服用4周。比较2组患者的临床疗效和药物不良反应的发生情况,并分析2型糖尿病与根除Hp的关系。结果治疗后,试验组和对照组的总有效率分别为86.06%(105/122例)和94.32%(166/176例),差异有统计学意义(P0.05)。治疗后,试验组和对照组的Hp根除率分别为72.13%(88/122例)和86.93%(153/176例),差异有统计学意义(P0.05)。试验组的药物不良反应主要有恶心、腹泻和黑便;对照组的药物不良反应主要有恶心、腹泻和呕吐。试验组和对照组的药物不良反应发生率分别为9.83%(12/122例)和10.23%(18/176例),差异无统计学意义(P0.05)。结论治疗后,对照组的临床疗效优于试验组,提示临床应该要根据2型糖尿病和Hp阳性消化性溃疡的双重特点综合制定治疗方案,以提高临床疗效。
[Abstract]:Objective to observe the clinical effect of tetralogy therapy on type 2 diabetes mellitus with Helicobacter pylori positive peptic ulcer. Methods 176 patients with HP positive peptic ulcer as control group, 122 patients with type 2 diabetes mellitus with HP positive peptic ulcer were treated with rabeprazole 10 mg qd oral clarithromycin 0.25 g bid. Moxicillin 0.5 g bid oral bismuth potassium citrate 0.3 g Qid. Clarithromycin and amoxicillin were taken only 10 days before, the rest were taken for 4 weeks. To compare the clinical efficacy and adverse drug reaction in two groups, and to analyze the relationship between type 2 diabetes mellitus and HP eradication. Results after treatment, the total effective rates of the experimental group and the control group were 86.06% (105 / 122) and 94.32% (166 / 176), respectively. The difference was statistically significant (P0.05). After treatment, HP eradication rates were 72.13% (88 / 122 cases) and 86.93% (153 / 176 cases) in the experimental group and control group, respectively. The difference was statistically significant (P0.05). Adverse drug reactions in the trial group were mainly nausea, diarrhea and black stool, while those in the control group were nausea, diarrhea and vomiting. The incidence of adverse drug reactions in the experimental group and control group were 9.83% (12 / 122 cases) and 10.23% (18 / 176 cases) respectively (P0.05). Conclusion after treatment, the clinical efficacy of the control group is better than that of the experimental group, suggesting that the clinical treatment should be based on the dual characteristics of type 2 diabetes mellitus and HP positive peptic ulcer, so as to improve the clinical efficacy.
【作者单位】：重庆医科大学第二临床学院;重庆医科大学附属第二医院消化内科;重庆医科大学附属第一医院心内科;重庆医药高等专科学校医学美容教研室;
【基金】：国家自然科学基金资助项目(81271598) 重庆市卫生局医学科研重点基金资助项目(2012-1-035)
【分类号】：R573.1;R587.1

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