隐源性肝硬化患者发生肝细胞肝癌的危险因素探讨

发布时间：2018-07-03 09:15

本文选题：肝硬化 + 高血压　；参考：《中国全科医学》2015年27期

【摘要】：目的分析隐源性肝硬化(CC)患者发生肝细胞肝癌(HCC)的危险因素。方法回顾性收集新疆医科大学第一附属医院2009年7月—2014年7月符合纳入与排除标准的CC患者241例。按照诊断结果将患者分为单纯CC组(222例)和CC合并HCC组(19例)。收集并比较患者性别、年龄、民族、体质量、是否合并高血压、是否合并糖尿病、恶性肿瘤家族史、药物过敏史、Child-Pugh评分、血红蛋白、平均红细胞体积、球蛋白、三酰甘油、总胆固醇、尿酸、肌酐、尿蛋白等指标。结果单因素条件Logistic回归分析结果显示,年龄、是否合并高血压、尿蛋白是CC患者发生HCC的影响因素(P0.05)。多因素非条件Logistic逐步回归分析结果显示,以α=0.05为显著水准,进入回归模型的变量有年龄、合并高血压(P0.05)。结论高血压和年龄高是CC患者发生HCC的危险因素,应对CC患者血压升高及年龄予以重视,正确评估,以降低其发生HCC的风险。
[Abstract]:Objective to analyze the risk factors of hepatocellular carcinoma (HCC) in patients with cryptogenic cirrhosis (CC). Methods 241 CC patients who met the criteria of inclusion and exclusion from July 2009 to July 2014 in the first affiliated Hospital of Xinjiang Medical University were retrospectively collected. According to the diagnostic results, the patients were divided into simple CC group (222 cases) and CC with HCC group (19 cases). Gender, age, nationality, body mass, hypertension, diabetes mellitus, family history of malignant tumor, history of drug allergy, Child-Pugh score, hemoglobin, mean erythrocyte volume, globulin, triglyceride were collected and compared. Total cholesterol, uric acid, creatinine, urine protein and other indicators. Results univariate conditional logistic regression analysis showed that age, hypertension and urine protein were the influential factors of HCC in CC patients (P0.05). The results of multivariate conditional logistic regression analysis showed that the significant level of 伪 -0. 05 was age and hypertension was associated with hypertension (P0.05). Conclusion Hypertension and high age are the risk factors of HCC in CC patients. It is necessary to pay attention to the increase of blood pressure and age in CC patients and evaluate them correctly in order to reduce the risk of HCC.
【作者单位】：新疆医科大学第一附属医院肝病科;新疆维吾尔自治区人民医院放疗科;新疆医科大学附属肿瘤医院心功能科;
【基金】：新疆维吾尔自治区自然科学基金资助项目(2013211A099)
【分类号】：R575.2;R735.7

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