蒲元和胃胶囊参与的序贯疗法治疗Hp相关性胃病的临床观察
发布时间:2018-07-04 16:30
本文选题:蒲元和胃 + 序贯疗法 ; 参考:《山东中医药大学》2014年硕士论文
【摘要】:目的:通过对蒲元和胃胶囊联合PPI与抗生素采用序贯疗法治疗Hp相关性胃病(主要包括慢性胃炎与消化性溃疡)的临床观察,分析其疗效与适应症,,为采用此方案个体化治疗Hp相关性胃病提供资料。 方法:300例Hp阳性慢性胃炎与消化性溃疡患者,按随机原则分为两组,治疗组采用蒲元和胃胶囊联合PPI和抗生素行序贯治疗,对照组采用西药三联疗法。观察记录两组患者总疗效情况、胃镜疗效、各病种疗效、中医证型疗效、Hp根除率、不良反应发生等情况。 结果:280例完成治疗与复查。治疗组与对照组总有效率分别为96.6%和85.9%,总显效率分别为88.3%和69.6%,差异有统计学意义(P0.05)。胃镜疗效方面两组有效率为97.9%和96.3%,显效率为89.7%和86.7%,差异无统计学意义(P0.05)。Hp根除率方面两组分别为92.4%和93.3%,差异无统计学意义(P0.05)。各病种疗效方面,慢性浅表性胃炎的治疗上两组有效率与显效率差异无统计学意义(P0.05),慢性萎缩性胃炎、胃和十二指肠溃疡的治疗上有效率与显效率差异有统计学意义(P0.05)。在中医证型疗效方面,两组在中医9个分型中的6个证型的有效率与显效率上差异有统计学意义(P0.05)。治疗组的不良反应少于对照组。 结论:本方案在达到较高Hp根除率的基础上疗效更好、不良反应少,较适合在中医辨证的基础上对Hp相关性胃病进行个体化治疗。
[Abstract]:Objective: to observe the clinical effects and indications of PPI combined with PPI and antibiotics in the treatment of HP associated gastropathy (including chronic gastritis and peptic ulcer). To provide data for individualized treatment of HP-associated gastropathy. Methods 300 patients with HP positive chronic gastritis and peptic ulcer were randomly divided into two groups. The treatment group was treated with Puyuanghe capsule combined with PPI and antibiotics, and the control group was treated with western medicine triple therapy. To observe and record the total curative effect of the two groups, the curative effect of gastroscope, the curative effect of each disease, the curative effect of TCM syndrome type and the eradication rate of HP, the occurrence of adverse reaction and so on. Results the treatment and reexamination were completed in 280 cases. The total effective rates of the treatment group and the control group were 96.6% and 85.9%, respectively. The total effective rate was 88.3% and 69.6%, respectively. The difference was statistically significant (P0.05). The effective rate of gastroscopy was 97.9% and 96.3%, the effective rate was 89.7% and 86.7%, the difference was not statistically significant (P0.05). The eradication rate of HP in the two groups was 92.4% and 93.3%, respectively (P0.05). There was no significant difference between the two groups (P0.05). In the treatment of chronic superficial gastritis, there was no significant difference in the effective rate and the effective rate between the two groups (P0.05), while the effective rate and the effective rate in the treatment of chronic atrophic gastritis, gastric and duodenal ulcer were statistically significant (P0.05). In TCM syndromes, the effective rate and effective rate of 6 syndromes in 9 types of TCM were significantly different between the two groups (P0.05). The adverse reactions in the treatment group were less than those in the control group. Conclusion: this scheme has better curative effect and fewer adverse reactions on the basis of higher eradication rate of HP. It is more suitable for individualized treatment of HP related gastropathy on the basis of TCM syndrome differentiation.
【学位授予单位】:山东中医药大学
【学位级别】:硕士
【学位授予年份】:2014
【分类号】:R573
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