超声辐射力脉冲技术分级量化肝纤维化的实验研究

发布时间：2018-07-04 16:41

本文选题：超声辐射力 + 累计相位　；参考：《电子科技大学学报》2017年06期

【摘要】：肝纤维化是慢性肝病进展到肝硬化的中间阶段,肝纤维化不同分期的硬度量化具有重要的临床意义,但目前其弹性参数检测尚不准确。该文基于超声辐射力脉冲(ARFI)技术,提出一种对肝脏组织弹性系数进行量化的新方法。通过ARFI技术产生超声辐射力推动聚焦处组织产生微小纵向位移,获取激励前后的超声回波信号,采用累积相位互相关算法检测微小位移,评估其分级肝纤维化程度的可行性;再通过Voigt粘弹性模型建立特定声辐射力下弹性系数与组织受激产生应变的关系曲线,从而获得不同分期肝纤维化组织弹性系数的绝对值。对不同分期的兔子肝脏进行实验,结果表明如果采用单一辐射力获得的纵向位移进行分期结果不稳定,而应采用多种声强度和多种脉冲宽度的辐射力下的平均纵向位移。最终得到的肝纤维化不同分期的弹性系数为:F0:(11.95±1.91)k Pa,F1:(13.28±1.89)k Pa,F2:(15.40±1.98)k Pa,F3:(16.83±2.01)k Pa,F4:(18.52±2.28)k Pa。实验结果实现了区分不同肝纤维化等级的兔子肝脏,并得到不同等级相对应的弹性参数值,为临床上肝纤维化的准确检查和诊断提供了新的方法和手段。
[Abstract]:Liver fibrosis is the intermediate stage from chronic liver disease to liver cirrhosis. The hardness quantification of different stages of liver fibrosis has important clinical significance, but the measurement of elastic parameters is not accurate. A new method for quantifying the elastic coefficient of liver tissue is presented based on the ultrasonic power pulse (ARFI) technique. The ultrasonic radiation force produced by ARFI can promote the tiny longitudinal displacement of the focus tissue and obtain the ultrasonic echo signal before and after the excitation. The cumulative phase cross-correlation algorithm is used to detect the tiny displacement and to evaluate the feasibility of grading liver fibrosis. Based on Voigt viscoelastic model, the relationship between the elastic coefficient and the induced strain of the tissue under specific acoustic radiation was established, and the absolute value of the elastic coefficient of liver fibrosis in different stages was obtained. The experimental results of rabbit liver in different stages show that if the longitudinal displacement obtained by a single radiation force is unstable, the average longitudinal displacement under various acoustic intensity and pulse width should be adopted. The elastic coefficient of different stages of hepatic fibrosis was (11.95 卤1.91) k PaF1: (13.28 卤1.89) k PaF2: (15.40 卤1.98) k PaF3: (16.83 卤2.01) k PaF4: (18.52 卤2.28) kPa. The experimental results show that the rabbit liver with different grades of liver fibrosis can be distinguished and the corresponding elastic parameters can be obtained, which provides a new method and method for the accurate examination and diagnosis of hepatic fibrosis.
【作者单位】：四川大学生物医学工程系;四川大学华西医院超声科;
【基金】：国家自然科学基金(81301286) 教育部博士点基金(20130181120001) 四川省科技支撑项目(2014GZ0005-7)
【分类号】：R575.2

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