经量化扩散加权成像与超声剪切波弹性成像对乙型肝炎相关性肝纤维化比较分析

发布时间：2018-07-06 12:08

本文选题：肝炎 + 乙型　；参考：《中国临床医学影像杂志》2017年06期

【摘要】：目的 :探讨经量化的MRI扩散加权成像(Diffusion weighted imaging,DWI)与超声剪切波弹性成像(Shear wave elastrography,SWE)对乙型肝炎肝纤维化的诊断价值,并比较分析二者的临床意义。方法 :54例病例组和13例健康受检者同时行DWI和SWE,分别测得ADC值和杨氏弹性模量值(Emean),采用单因素方差分析和LSD对其分析比较;并采用Spearman等级相关检测肝纤维化程度与ADC值和Emean值的相关性。结果:随肝纤维化程度加重,ADC值与肝纤维化程度呈高度负相关(r=-0.801,P0.05),Emean值与肝纤维化程度呈高度正相关(r=0.882,P0.05)。S0和S1组、S2和S3组、S3和S4组肝脏ADC值差异无统计学意义。Emean值在有无肝纤维化组间差异有统计学意义;不同程度肝纤维化组间差异有显著性。ADC值和Emean值诊断不同等级肝纤维化均具有较高的效能。结论 :在肝纤维化病理分级及相关性分析中,Emean值和ADC值对诊断不同等级肝纤维化有较高价值;SWE更具优势。
[Abstract]:Objective: to evaluate the diagnostic value of weighted diffusion weighted imaging (DWI) and shear wave elastography (Shear wave imaging) in the diagnosis of hepatic fibrosis in hepatitis B patients, and to compare their clinical significance. Methods the ADC values and Young's modulus of elasticity (Emean) were measured by DWI and SWE in 54 cases and 13 healthy subjects respectively. The results were compared by single factor ANOVA and LSD. Spearman grade correlation was used to detect the correlation between the degree of hepatic fibrosis and ADC value and Emean value. Results: with the severity of hepatic fibrosis, ADC value was negatively correlated with hepatic fibrosis degree (r = -0.801P 0.05). Emean value was positively correlated with liver fibrosis degree (r = 0.882P 0.05). There was no significant difference in ADC value between S0 group and S1 group and S3 group and S4 group. Emean value was significant in S3 and S4 groups. There was no significant difference in ADC value between S3 and S4 groups. There was no significant difference in Emean value between S0 and S1 groups. The difference between the groups without hepatic fibrosis was statistically significant. There were significant differences between groups with different degrees of hepatic fibrosis. ADC value and Emean value had high efficiency in the diagnosis of liver fibrosis of different grades. Conclusion: in the pathological grading and correlation analysis of hepatic fibrosis, Emean value and ADC value have higher value in the diagnosis of liver fibrosis of different grades. SWE has more advantages.
【作者单位】：郑州人民医院;
【基金】：河南省科技攻关项目(142102310152)
【分类号】：R512.62;R575.2

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