4种评分系统在非酒精性脂肪肝病肝纤维化程度的诊断效能评价

发布时间：2018-07-07 21:56

  本文选题：非酒精性脂肪肝病 + BARD评分　； 参考：《中国现代医学杂志》2017年22期

【摘要】：目的评价天冬氨酸氨基转移酶血小板比率指数(APRI)、BARD(BMI,AST/ALT,DM)评分、BAAT(BMI,年龄,ALT,TG)评分和非酒精性脂肪肝病(NAFLD)纤维化评分(NFS)4种肝纤维化评分系统在该院NAFLD患者中的临床应用价值,并探索联合使用评分系统的应用效能。方法选取2013年7月~2016年9月确诊为NAFLD的患者为研究对象。测定其临床及实验室指标,计算NFS、APRI、BARD、BAAT得分,并以组织学结果为参照,评价这些系统的诊断价值。结果 96例NAFLD患者中66例有肝纤维化。经计算,NFS系统诊断NAFLD患者是否有肝纤维化的敏感性为1.92%,特异性为100%;APRI系统的敏感性为7.58%,特异性为93.33%;BARD系统的敏感性为63.64%,特异性为16.67%;BAAT系统的敏感性为0,特异性为94.74%。NFS联合APRI的敏感性为10.71%,特异性为90%;BARD联合BAAT的敏感性为76.36%,特异性为10.34%。结论当联合使用BARD和BAAT时,可获得高敏感性,故可用于NAFLD的初步筛查;当单独使用NFS或APRI时,其特异性较高,可用于NAFLD的进一步鉴别诊断。
[Abstract]:Objective to evaluate the clinical application value of aspartate aminotransferase platelet ratio index (APRI) BARD (BMIAST / alt DM) score BAAT (BMIs) and nonalcoholic fatty liver disease (NAFLD) fibrosis scoring system (NFS) in patients with NAFLD in our hospital. And explore the application efficiency of the joint use scoring system. Methods patients diagnosed with NAFLD from July 2013 to September 2016 were selected as study subjects. The clinical and laboratory indexes were measured, and the BAAT scores were calculated. The diagnostic value of these systems was evaluated according to the histological results. Results 66 of 96 NAFLD patients had hepatic fibrosis. The sensitivity of the NFS system in diagnosing hepatic fibrosis in NAFLD patients was 1.922.The specificity of APRI system was 7.58, the specificity was 93.330.The sensitivity of Bard system was 63.64. The sensitivity of BAAT system was 0, and the specificity was 94.74.NFS. The sensitivity of APRI was 10.71, the specificity was 90% and the sensitivity of BAAT was 76.36 and the specificity was 10.34. Conclusion the combination of Bard and BAAT can obtain high sensitivity, so it can be used in the preliminary screening of NAFLD, and the specificity of NAFLD is higher when using NFS or APRI alone, which can be used for further differential diagnosis of NAFLD.
【作者单位】： 郑州人民医院消化科;新乡医学院第一附属医院消化科;
【分类号】：R575
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本文编号：2106398