白介素1家族在脂肪肝疾病中的作用及机制研究进展

发布时间：2018-07-08 07:42

  本文选题：酒精性脂肪肝 + 非酒精性脂肪肝　； 参考：《中国药理学通报》2017年06期

【摘要】：白介素1(interleukin-1,IL-1)炎症因子家族在脂肪肝疾病进程中发挥关键作用。IL-1炎性因子家族参与脂肪肝疾病发生发展的各个阶段,如肝炎、肝纤维化、肝硬化、肝癌,抑制IL-1信号转导途径可能是目前治疗脂肪肝疾病的有效策略。IL-1炎症因子家族多环节多途径地整体调节脂肪肝疾病的发生发展,有望成为有效治疗脂肪肝的药物靶点,指导脂肪肝治疗药物的筛选。该文对近年来关于IL-1炎症因子家族在酒精性和非酒精性脂肪肝疾病中的作用及机制研究进行全面综合、整理和归纳。
[Abstract]:Interleukin-1 (IL-1) inflammatory factor family plays a key role in the progression of fatty liver disease. IL-1 inflammatory factor family is involved in various stages of fatty liver disease, such as hepatitis, liver fibrosis, liver cirrhosis, liver cancer. Inhibition of IL-1 signal transduction pathway may be an effective strategy for the treatment of fatty liver disease at present. IL-1 inflammatory factor family regulates the occurrence and development of fatty liver disease in many ways, which is expected to become an effective drug target for the treatment of fatty liver. To guide the screening of drugs for the treatment of fatty liver. The role and mechanism of IL-1 inflammatory factor family in alcoholic and non-alcoholic fatty liver diseases were comprehensively synthesized, summarized and summarized in this paper.
【作者单位】： 江苏省中药药效与安全性评价重点实验室;江苏省中药功效物质重点实验室;南京中医药大学中药品质与效能国家重点实验室(培育);
【基金】：国家自然科学基金资助项目(No 31571455,31401210,31600653,81600483,81270514) 江苏省自然科学基金资助项目(No BK20140955) 江苏省中药药效与安全性评价重点实验室开放课题(No JKLPSE 201502) 江苏高校优势学科建设工程资助项目(No PAPD)
【分类号】：R575.5
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本文编号：2106714