清肝利胆胶囊联合左氧氟沙星治疗肝胆湿热型慢性胆囊炎临床疗效观察

发布时间：2018-07-10 06:33

本文选题：清肝利胆胶囊 + 左氧氟沙星　；参考：《中药药理与临床》2017年01期

【摘要】：目的:观察清肝利胆胶囊联合左氧氟沙星治疗肝胆湿热型慢性胆囊炎的临床疗效。方法:纳入2014年5月至2015年5月我院收治的中医症候为肝胆湿热型的慢性胆囊炎患者98例,按随机数字表法分为观察组49例和对照组49例。对照组给予左氧氟沙星治疗,观察组患者在对照组基础上加用清肝利胆胶囊联合治疗。记录并分析两组患者治疗前和治疗后中医症候积分变化、肿瘤坏死因子(TNF-α)、β-内啡呔(β-EP)、白细胞(WBC)、血清丙二醛(MDA)和血清超氧化歧化酶(SOD)水平的变化、胆囊B超疗效和临床疗效。结果:观察组治疗后中医症状积分为(6.73±2.07)分,显著低于对照组(10.02±2.33)分。观察组治疗后TNF-α、β-EP和WBC水平分别为(0.8±0.1ng/ml、150.1±10.4pg/ml、7.11±0.36×109/L),均明显低于对照组(1.1±0.1ng/ml、170.0±13.2pg/ml、8.14±0.47×109/L)。观察组治疗后MDA和SOD水平分别为(13.1±0.5nmol/ml、682.1±35.7ng/ml),均明显优于对照组(14.9±0.8nmol/ml、608.9±32.5ng/ml);4观察组治疗后胆囊B超疗效总有效率为81.63%,显著高于对照组59.18%。5观察组治疗后临床疗效总有效率为85.71%,显著高于对照组61.22%。6治疗后观察组胆壁增厚、胆囊壁毛糙、胆囊体积变形和患者比例分别为(20.41%、22.45%、12.24%),均明显低于对照组(42.86%、46.94%、30.61%)。结论:清肝利胆胶囊联合左氧氟沙星可有效降低肝胆湿热型慢性胆囊炎患者体内炎症水平,调节体内相关因子水平,提高慢性胆囊炎的治疗效果。
[Abstract]:Objective: to observe the clinical effect of Qinggan Lidan capsule combined with levofloxacin on chronic cholecystitis of damp-heat type of liver and gallbladder. Methods: from May 2014 to May 2015, 98 cases of chronic cholecystitis with the syndrome of dampness and heat of liver and gallbladder were included in our hospital. According to the method of random number table, they were divided into observation group (n = 49) and control group (n = 49). The patients in the control group were treated with levofloxacin and the patients in the observation group were treated with Qinggan Lidan capsule on the basis of the control group. The changes of TCM symptom score, tumor necrosis factor (TNF- 伪), 尾 -endorphin (尾 -EP), white blood cell (WBC), serum malondialdehyde (MDA) and serum superoxide dismutase (SOD) before and after treatment were recorded and analyzed. Results: the score of TCM symptom in the observation group was (6.73 卤2.07), which was significantly lower than that in the control group (10.02 卤2.33). After treatment, the levels of TNF- 伪, 尾 -EP and WBC in the observation group were (0.8 卤0.1 ng / ml) 150.1 卤10.4 PG / ml (7.11 卤0.36 脳 10 9 / L), which were significantly lower than those in the control group (1.1 卤0.1 ng / ml, 170.0 卤13.2 PG / ml, 8.14 卤0.47 脳 109 / L). After treatment, the levels of MDA and sod were (13.1 卤0.5nmol / ml, 682.1 卤35.7ng/ml) in the observation group, respectively, which were significantly superior to those in the control group (14.9 卤0.8nmol / ml, 608.9 卤32.5ng/ml). The total effective rate of B-ultrasound in the observation group was 81.630.It was significantly higher than that in the control group (59.18.5). The total effective rate was 85.71and significantly higher than that in the control group (85.71g). The gallbladder wall was thickened in the observation group after treatment with 61.22.6 in the control group. The gallbladder wall was rough, the volume deformation of gallbladder and the proportion of patients were 12.24%, respectively, which were significantly lower than those in the control group (42.86%, 46.94%). Conclusion: Qinggan Lidan capsule combined with levofloxacin can effectively reduce the level of inflammation in patients with chronic cholecystitis of damp-heat type of liver and gallbladder, regulate the level of related factors in the body and improve the therapeutic effect of chronic cholecystitis.
【作者单位】：广州中医药大学;深圳市南山人民医院;中国中医科学院;
【分类号】：R575.7

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