血清降钙素原与内毒素对肝硬化患者腹水感染的诊断分析

发布时间：2018-07-13 12:45

【摘要】：目的探讨血清降钙素原(PCT)和内毒素(ETX)水平对肝硬化患者腹水感染的诊断效果,为肝硬化患者腹水感染的诊断提供参考依据。方法选取2013年3月-2014年9月于医院治疗的134例肝硬化伴腹水患者为研究对象,根据腹水细菌培养结果,分为腹水感染组61例及非腹水感染组73例,采用ELISA方法和偶氮显色基质法检测两组患者的PCT及ETX水平;采用SPSS16.0软件对数据进行分析。结果 61例腹水细菌培养阳性的肝硬化腹水患者,检出病原菌以大肠埃希菌和粪肠球菌为主;腹水感染组患者的血清PCT及ETX水平均显著高于非腹水感染组,差异有统计学意义(P0.05);采用ROC曲线确定PCT及ETX的诊断阈值分别为0.5ng/ml、10pg/ml;PCT及ETX的检测敏感性分别为为93.44%、81.97%,特异度分别为为84.93%、90.91%;PCT及LPS在诊断腹水感染时ROC曲线下面积分别为0.923、0.901。结论血清PCT和ETX水平对腹水感染的诊断有较好的敏感度和特异度,可作为诊断腹水感染快速而准确的辅助指标。
[Abstract]:Objective to investigate the effect of serum procalcitonin (PCT) and endotoxin (ETX) levels on the diagnosis of ascites infection in patients with cirrhosis. Methods 134 cirrhotic patients with ascites treated in hospital from March 2013 to September 2014 were divided into ascites infection group (n = 61) and non-ascites infection group (n = 73). The levels of PCT and ETX were detected by Elisa and azo chromogenic matrix method, and the data were analyzed by SPSS 16.0 software. Results among 61 patients with ascites, Escherichia coli and Enterococcus faecalis were the main pathogens, and the levels of serum PCT and ETX in ascites infection group were significantly higher than those in non-ascites infection group. The diagnostic threshold of PCT and ETX by ROC curve was 0.5 ng / ml ~ (10) PG / ml ~ (-1) PCT and ETX, respectively. The sensitivity of PCT and ETX was 93.44 ~ 81.97, and the specificity of PCT and LPS in the diagnosis of ascites infection were 0.923 ~ 0.901, respectively. Conclusion Serum PCT and ETX levels have good sensitivity and specificity in the diagnosis of ascites infection and can be used as a rapid and accurate auxiliary index for the diagnosis of ascites infection.
【作者单位】：浙江省立同德医院感染科;浙江大学附属第一医院传染科;
【基金】：浙江省卫生厅基金资助项目(2012013)
【分类号】：R575.2

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