溃疡性结肠炎肠道菌群失调与免疫球蛋白水平的相关性

发布时间：2018-07-13 13:17

【摘要】：目的:探讨溃疡性结肠炎(UC)患者肠道菌群失调、血清免疫球蛋白水平及疾病活动度的相关性,确定粪便球杆比对评估UC患者菌群失调的临床价值。方法:选取2013年1月至2015年5月北京大学第一医院就诊的401例UC患者为研究对象,根据Mayo评分分为缓解期、活动期轻、中、重度4组,回顾粪便球杆比、血清免疫球蛋白(IgG、IgM、IgA、C3、C4)检测结果,根据粪便球杆比对菌群失调分度,分析病情活动度、肠道菌群失调、血清免疫球蛋白的相关性。结果:随疾病活动度升高,菌群失调加重(Spearman相关系数=0.295,P0.05),血清IgM下降,C3升高,C4在轻中度活动组显著升高。菌群失调程度与血清免疫球蛋白相关,随肠道菌群失调加重,血清IgM、IgA下降,C3上升(P0.05)。结论:肠道菌群失调与UC患者的疾病活动度相关,且与机体体液免疫紊乱有关,通过检测粪便球杆比、免疫球蛋白及补体,对UC患者病情判断及治疗有指导意义。
[Abstract]:Objective: to investigate the correlation among intestinal flora disorder, serum immunoglobulin level and disease activity in patients with ulcerative colitis (UC), and to determine the clinical value of stool club ratio in evaluating dysbacteriosis in UC patients. Methods: 401 UC patients in the first Hospital of Peking University from January 2013 to May 2015 were selected as study subjects. According to Mayo score, 401 UC patients were divided into 4 groups: remission period, light, moderate and severe stage. The results of serum immunoglobulin (IgG) were analyzed according to the ratio of fecal ball rod to microflora, and the correlation of disease activity, intestinal dysbacteriosis and serum immunoglobulin was analyzed. Results: with the increase of disease activity, the dysbacteriosis increased (Spearman correlation coefficient 0.295), and serum IgM decreased and C3 increased significantly in mild to moderate activity group. The degree of dysbacteriosis was related to serum immunoglobulin. With the aggravation of intestinal dysbacteriosis, serum IgA decreased and C3 increased (P0.05). Conclusion: intestinal dysbacteriosis is related to the disease activity of UC patients and to the humoral immune disorder. The detection of stool ratio, immunoglobulin and complement may be helpful to the diagnosis and treatment of UC patients.
【作者单位】：北京大学第一医院消化内科;
【分类号】：R574.62

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