低聚果糖影响结肠炎小鼠肠黏膜的研究
发布时间：2018-07-16 21:56
【摘要】：目的观察低聚果糖(FOS)对小鼠肠道黏膜的影响,并探讨其对结肠炎的治疗作用及可能机制。方法用5%DSS诱导建立小鼠结肠炎模型,将30例小鼠随机分成正常组、模型组、FOS组。FOS组在模型建立后饮用配置好的5%FOS溶液。观察各组疾病活动指数(DAI),实验结束后观察结肠长度变化、组织学损伤评分、菌群计数统计以及IL-6、IL-33、TNF-α、RegⅢγ的表达。结果 FOS组DAI(P0.000 1)及组织学损伤评分(P0.000 1)明显低于模型组,模型组小鼠结肠质地变硬且黏膜皱褶消失(P0.01),FOS组结肠致病菌与模型组相比显著减少(P0.01),FOS组结肠IL-6(P0.05)、IL-33(P0.05)的表达量相比于模型组显著降低,TNF-α(P0.05)、RegⅢγ(P0.05)虽有降低但无统计学意义。结论低聚果糖能够改善结肠炎小鼠有益菌群的比例,降低促炎细胞因子IL-33及IL-6的水平,减轻肠道炎症反应。
[Abstract]:Objective to observe the effect of fructooligosaccharide (FOS) on intestinal mucosa in mice and to explore the therapeutic effect and possible mechanism of FOS on colitis. Methods the colitis model of mice was induced by 5 DSS. 30 mice were randomly divided into normal group and FOS group. The FOS group drank the 5 FOS solution after the model was established. Disease activity index (Dai), colonic length, histological injury score, microflora count and the expression of IL-6 and IL-3TNF- 伪 TNF- 伪 Reg 鈪，
本文编号：2127790
[Abstract]:Objective to observe the effect of fructooligosaccharide (FOS) on intestinal mucosa in mice and to explore the therapeutic effect and possible mechanism of FOS on colitis. Methods the colitis model of mice was induced by 5 DSS. 30 mice were randomly divided into normal group and FOS group. The FOS group drank the 5 FOS solution after the model was established. Disease activity index (Dai), colonic length, histological injury score, microflora count and the expression of IL-6 and IL-3TNF- 伪 TNF- 伪 Reg 鈪，
本文编号：2127790
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