PTGER4基因多态性与炎症性肠病易感性的Meta分析

发布时间：2018-07-16 22:33

【摘要】：目的:系统评价人群中PTGER4基因多态性与炎症性肠病(Inflammatory bowel disease,IBD)的关系。方法:检索Pub Med、Embase、Web of Science中2016年2月29日以前发表的相关病例对照研究文献,选择符合质量要求的研究。用STATA12.0软件进行Meta分析,计算合并OR值及其95%可信区间(Confidence interval,CI),并通过敏感性分析判断结果的稳定性,通过Egger's检验分析发表偏倚。结果:共纳入20篇文献中发表的44项病例对照研究,包括25 179例克罗恩病(Crohn's disease,CD)病例、5 261例溃疡性结肠炎(Ulcerative colitis,UC)病例和44 652名对照。Meta分析结果表明,rs4613763T/C多态性与CD关系的等位基因频率、共显性模型、显性模型、隐性模型分析的合并OR值(95%CI)分别是1.24(1.06~1.45)、1.32(1.06~1.64)、1.25(1.06~1.48)和1.28(1.03~1.59);rs17234657T/G多态性与CD关系四种模型分析合并OR值(95%CI)为:1.43(1.34~1.52)、2.12(1.70~2.63)、1.46(1.36~1.57)和1.93(1.56~2.40);rs4495224A/C多态性与CD关系的四种模型分析合并OR值(95%CI)为:1.05(0.79~1.41)、1.08(0.62~1.88)、1.12(0.75~1.65)和1.00(0.67~1.49);rs9292777G/T多态性与CD关系的四种模型分析合并OR值(95%CI)为:0.77(0.67~0.88)、0.59(0.51~0.69)、0.73(0.61~0.87)和0.68(0.59~0.79);rs1373692T/G多态性与CD关系的四种模型分析合并OR值(95%CI)为:1.23(0.96~1.57)、1.39(0.74~2.59)、1.26(0.74~2.13)和1.31(1.00~1.72)。rs4613763T/C多态性与UC易感性分析的四种模型分析合并OR值(95%CI)为:1.30(1.17~1.44)、1.73(1.16~2.59)、1.32(1.17~1.48)和1.64(1.10~2.45)。结论:rs17234657T/G、rs4613763T/C和rs9292777G/T多态性与CD易感性相关;rs4613763T/C多态性与UC的易感性相关。
[Abstract]:Objective: to evaluate the relationship between PTGER4 gene polymorphism and inflammatory bowel disease (IBD). Methods: the relevant case-control studies published before February 29, 2016 in Pub Medbase Web of Science were searched and selected to meet the quality requirements. Meta-analysis with STATA12.0 software was used to calculate the combined OR value and its 95% confidence interval (CI). The stability of the results was judged by sensitivity analysis and the publication bias was analyzed by Eggers-test. Results: 44 case-control studies published in 20 articles were included. The allelic frequency and codominant model of alleles in 25 179 cases of Crohn's disease (CD) and 5 261 cases of ulcerative colitis (UC) and 44 652 cases of control. Meta-analysis showed that rs4613763T / C polymorphism was associated with CD. 闅愭，

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