不同程度肝损伤患者红细胞分布宽度与凝血酶原时间的差异

发布时间：2018-07-17 05:12

【摘要】：目的探讨不同程度肝损伤患者红细胞分布宽度(RDW)与凝血酶原时间(PT)的变化趋势及其临床意义。方法选取重庆医科大学附属第二医院2014年1月至2015年6月住院乙型肝炎患者100例(乙肝组),乙型肝炎肝硬化患者100例(肝硬化组),乙型肝炎病毒相关的原发性肝细胞癌患者50例(肝癌组),以及同期健康体检者100例(对照组)。采用Sysmex XE-2100全自动血细胞分析仪检测所有受试者外周血RDW与红细胞平均体积(MCV),采用Stago Rack Evolutio全自动凝血仪检测PT,并进行比较分析。结果除肝硬化组与肝癌组RDW比较,差异无统计学意义(P=0.099),其余各组间比较差异均有统计学意义(P0.01),随着病情加重,RDW逐渐变宽;各组间MCV比较,差异无统计学意义(P0.05);除乙肝组与肝硬化组PT比较,差异无统计学意义(P=0.234),其余各组间比较差异均有统计学意义(P0.01),随着病情加重,PT逐渐延长。结论RDW、PT的增加与肝损伤的严重程度相关,RDW可能成为预测患者肝损伤程度的指标。
[Abstract]:Objective to investigate the changes of erythrocyte distribution width (RDW) and prothrombin time (PT) in patients with liver injury and their clinical significance. Methods from January 2014 to June 2015, 100 patients with hepatitis B (hepatitis B group), 100 patients with hepatitis B cirrhosis (cirrhosis group) and 100 patients with hepatitis B virus related primary liver were selected from the second affiliated Hospital of Chongqing Medical University. There were 50 cases of cell carcinoma (liver cancer group) and 100 cases of health examination (control group). The RDW and mean erythrocyte volume (MCV) in peripheral blood of all subjects were detected by Sysmex XE-2100 automatic blood cell analyzer and PTT was detected by Stago Rack Evolutio automatic coagulation instrument. Results there was no significant difference in RDW between liver cirrhosis group and liver cancer group (P0.099), but there was significant difference between the other groups (P0.01). The difference was not statistically significant (P0.05); except hepatitis B group and liver cirrhosis group PT, the difference was not statistically significant (P0. 234), the other groups were statistically significant (P0.01), with the severity of the disease gradually prolonged PT. Conclusion the increase of RDW PT is related to the severity of liver injury. RDW may be a predictor of liver injury in patients.
【作者单位】：重庆医科大学附属第二医院检验科;重庆市中医院骨科;
【基金】：重庆市卫生局项目资助(2012-2-60)
【分类号】：R512.62;R575;R735.7

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