四逆汤加味联合普芦卡必利治疗阳虚型慢性便秘患者

发布时间：2018-07-28 09:00

【摘要】：目的:探讨四逆汤加味联合普芦卡必利治疗阳虚型慢性便秘患者的临床疗效,为进一步提高阳虚型慢性便秘的治疗效果,减少药物不良反应提供新的治疗方案。方法:以本院2012年10月—2014年11月收治的278例阳虚型便秘患者作为研究对象,随机分为西药组和中西药结合组,每组各139例。西药组患者采用口服普芦卡必利治疗,中西药结合组采用口服普芦卡必利联合中药汤剂四逆汤加味治疗,两组均持续治疗12周。观察两组患者治疗前后临床症状积分、中医证候积分和结肠传输试验积分变化,并对治疗过程中的不良反应进行比较分析。结果:治疗后两组患者各项症状积分均较治疗前明显降低(P0.05),组间比较中西药结合组患者各项临床症状积分及中医临床证候积分均明显低于西药组(P0.05);结肠传输试验中西药结合组相比西药组其正常患者明显增加,中度患者明显减少(P0.05);治疗后中西药结合组在肛管静息压、肛管最大收缩压、肛门括约肌长度以及持续挤压时间方面的改善均明显优于西药组(P0.05);治疗后与西药组相比,中西药结合组患者痊愈率明显增加,无效率明显降低(P0.05);治疗过程中中西药结合组患者不良反应发生率明显低于对照组(P0.05),差异均具有统计学意义。结论:联合四逆汤加味治疗阳虚型慢性便秘能有效提高普芦卡必利对患者临床症状的改善作用,提高临床疗效,并显著减少患者不良反应的发生。
[Abstract]:Objective: to explore the clinical effect of Sini decoction combined with prucapride in the treatment of chronic constipation of Yang deficiency type, and to provide a new treatment scheme for further improving the therapeutic effect of chronic constipation of Yang deficiency type and reducing adverse drug reactions. Methods: 278 patients with Yang deficiency constipation were randomly divided into western medicine group and combination group with 139 cases in each group. The patients in the western medicine group were treated with oral prucapride, while the patients in the traditional Chinese medicine combined with western medicine group were treated by oral prucapride combined with Sini decoction. The two groups were treated continuously for 12 weeks. The clinical symptom score, TCM syndrome score and colonic transit test score were observed before and after treatment, and the adverse reactions during the treatment were compared and analyzed. Results: after treatment, the scores of symptoms in the two groups were significantly lower than those before treatment (P0.05), and the scores of clinical symptoms and clinical syndromes of Chinese medicine combined with western medicine group were significantly lower than those of the western medicine group (P0.05). Compared with the western medicine group, the normal patients in the combination group of traditional Chinese medicine and western medicine increased obviously. After treatment, the improvement of anal resting pressure, anal maximum systolic pressure, anal sphincter length and continuous compression time in the combination group were significantly better than those in the western medicine group (P0.05). The cure rate of the patients in the combination group was significantly higher than that in the control group (P0.05); the incidence of adverse reactions in the treatment group was significantly lower than that in the control group (P0.05), and the difference was statistically significant. Conclusion: combined with Sini decoction for chronic constipation of Yang deficiency type can effectively improve the clinical symptoms of patients with prucapride, improve the clinical efficacy, and significantly reduce the occurrence of adverse reactions.
【作者单位】：青海大学附属医院;
【分类号】：R574.62

【参考文献】