难治性炎症性肠病患者艰难梭状芽孢杆菌感染的临床分析

发布时间：2018-08-01 12:16

【摘要】：目的:探讨难治性炎症性肠病(Refractory inflammatory bowel disease)患者艰难梭状芽抱杆菌感染(Clostridium difficile infection,CDI)的临床特征,为临床防治艰难梭状芽孢杆菌感染提供依据。方法:连续性收集2013年1月至2016年1月医院收治的活动期难治性炎症性肠病患者92例和缓解期难治性炎症性肠病21例,采用荧光酶免疫法检测其粪便中艰难梭状芽孢杆菌感染的情况,分析艰难梭状芽孢杆菌感染的难治性炎症性肠病患者的临床特征。结果:19例活动期难治性炎症性肠病患者感染艰难梭状芽孢杆菌,感染率为20.65%,其中溃疡性结肠炎患者感染率为20.83%,克罗恩病患者感染率为20.45%。使用抗菌药物、万古霉素和处于活动期的难治性炎症性肠病患者艰难梭状芽孢杆菌感染率显著增高(P0.05)。溃疡性结肠炎患者病情严重度为重度、中度和轻度的患者艰难梭状芽孢杆菌感染率分别为44.44%、5.56%和8.33%,差异有统计学意义(P0.05)。结肠受累的患者艰难梭状芽孢杆菌感染率显著升高(P0.05)。克罗恩病结肠部位受累的患者艰难梭状芽孢杆菌感染率显著升高(P0.05)。结论:难治性炎症性肠病患者艰难梭状芽孢杆菌感染率较高,与抗菌药物、万古霉素、病情活动度、病情严重度和结肠受累有关。
[Abstract]:Objective: to investigate the clinical features of Clostridium diffracta infection (Clostridium difficile) in patients with refractory inflammatory bowel disease (Refractory inflammatory bowel disease), and to provide a basis for clinical prevention and treatment of Clostridium diffculent infection. Methods: from January 2013 to January 2016, 92 patients with active refractory inflammatory bowel disease and 21 patients with remission refractory inflammatory bowel disease were collected. Fluorescent enzyme immunoassay was used to detect the infection of Clostridium diffracta in feces and to analyze the clinical features of the patients with refractory inflammatory bowel disease. Results the infection rate was 20.65 in 19 patients with active refractory inflammatory bowel disease. The infection rate was 20.83 in ulcerative colitis and 20.45in Crohn's disease. The infection rate of Clostridium difficulty in patients with antibiotic, vancomycin and active refractory inflammatory bowel disease was significantly increased (P0.05). The severity of ulcerative colitis was severe and the infection rate of moderate and mild patients was 44.445.56% and 8.33 respectively. The difference was statistically significant (P0.05). The infection rate of Clostridium difficulty was significantly increased in patients with colon involvement (P0.05). The infection rate of Clostridium difficulty in patients with Crohn's disease was significantly higher than that in patients with colon involvement (P0.05). Conclusion: the infection rate of Clostridium difficulty in patients with refractory inflammatory bowel disease is high, which is related to antibiotics, vancomycin, disease activity, severity of disease and colonic involvement.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R574

【参考文献】