血清甘油三酯水平与急性胰腺炎病情严重程度及预后相关性分析
发布时间：2018-08-10 19:02
【摘要】：目的探讨血清甘油三酯(triglyceride,TG)水平与急性胰腺炎(acute pancreatitis,AP)患者病情严重程度及预后的相关性。方法收集2012年1月至2015年9月期间本科466例AP患者资料,按血清TG值是否高于1.70 mmol/L分为正常组与升高组,升高组再分为轻、中、重组,比较病情严重程度及预后有无差异,以是否合并全身炎症反应综合征(systemic inflammatory response syndrome,SIRS)为因变量,进行Logistic回归分析。比较重度血脂升高组血液净化治疗前后指标。结果 466例AP患者中血脂升高组271例(58.2%),血脂正常组195例(41.8%),血脂升高组SIRS(42.8%vs23.6%,P0.01)、胸腔积液(55.0%vs 43.1%,P0.05)、病情程度(30.6%vs 19.5%,P0.01)明显高于正常组;组间器官功能障碍(13.7%vs 13.8%)差异无统计学意义(P0.05);随着TG升高,各组并发SIRS风险越高(P0.01)。Logistic回归分析TG与SIRS独立相关(OR=1.157,95%CI:1.102~1.215,P0.01)。重度血脂升高组中使用血液净化(29例)治疗后,TG水平、白细胞计数、APACHEⅡ评分与治疗前比较明显降低(P0.01)。结论 TG升高的AP患者预后更差,血清TG水平越高,SIRS发生率越高,但合并器官功能障碍无差异。血液净化能有效缓解血脂重度升高患者的病情。
[Abstract]:Objective to investigate the relationship between serum triglyceride (TG) level and severity and prognosis of patients with acute pancreatitis (AP). Methods data of 466 AP patients from January 2012 to September 2015 were collected and divided into normal group and elevated group according to whether the serum TG value was higher than 1.70 mmol/L. The elevated group was subdivided into mild, moderate and recombined group, and the severity and prognosis of AP were compared. Logistic regression analysis was performed to determine whether (systemic inflammatory response syndrome was associated with systemic inflammatory response syndrome (Sirs) as dependent variable. To compare the indexes before and after blood purification treatment in patients with severe hyperlipidemia. Results among 466 AP patients, 271 cases (58.2%) were in hyperlipidemia group, 195 cases (41.8%) in normal blood lipid group, SIRS (42.8 vs 23.6P0.01), pleural effusion (55.0%vs 43.1%, P0.05) and degree of illness (30.6%vs 19.5C) in AP group, but there was no significant difference in 13.7%vs 13.8% between groups (P0.05). The higher the risk of SIRS in each group was (P0.01). Logistic regression analysis showed that TG was independently correlated with SIRS (OR 1.15795 CI: 1.102 卤1.215P0.01). In the hyperlipidemia group (29 cases), the level of TG, white blood cell count and Apache 鈪，
本文编号：2175912
[Abstract]:Objective to investigate the relationship between serum triglyceride (TG) level and severity and prognosis of patients with acute pancreatitis (AP). Methods data of 466 AP patients from January 2012 to September 2015 were collected and divided into normal group and elevated group according to whether the serum TG value was higher than 1.70 mmol/L. The elevated group was subdivided into mild, moderate and recombined group, and the severity and prognosis of AP were compared. Logistic regression analysis was performed to determine whether (systemic inflammatory response syndrome was associated with systemic inflammatory response syndrome (Sirs) as dependent variable. To compare the indexes before and after blood purification treatment in patients with severe hyperlipidemia. Results among 466 AP patients, 271 cases (58.2%) were in hyperlipidemia group, 195 cases (41.8%) in normal blood lipid group, SIRS (42.8 vs 23.6P0.01), pleural effusion (55.0%vs 43.1%, P0.05) and degree of illness (30.6%vs 19.5C) in AP group, but there was no significant difference in 13.7%vs 13.8% between groups (P0.05). The higher the risk of SIRS in each group was (P0.01). Logistic regression analysis showed that TG was independently correlated with SIRS (OR 1.15795 CI: 1.102 卤1.215P0.01). In the hyperlipidemia group (29 cases), the level of TG, white blood cell count and Apache 鈪，
本文编号：2175912
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