非酒精性脂肪肝病与血清铁及铁蛋白的相关性研究

发布时间：2018-08-11 09:47

【摘要】：目的探讨超声影像学诊断非酒精性脂肪肝病(nonalcoholic fatty liver disease,NAFLD)与血清铁离子和血清铁蛋白浓度的相关性。方法应用经超声影像学方法诊断的40例非酒精性脂肪肝病者作为病例组及40例健康体检的非酒精性脂肪肝病者作为正常对照组,分别用原子吸收光谱法和放射免疫法检测血清铁和血清铁蛋白浓度。结果病例组的血清铁、铁蛋白测定值[(105.17±24.52)μg/d L,(146.57±68.28)ng/d L]与对照组[(85.45±26.84)μg/d L,(90.58±49.71)ng/d L]比较,差异有统计学意义(P0.01)。应用血清铁诊断NAFLD的受试者工作特征(receiver operating characteristic,ROC)曲线下面积、最佳阈值及敏感度、特异度、误诊率、漏诊率分别为0.69(P0.01)、123.5(μg/d L)、82.5%、60%、40%、17.5%。应用铁蛋白诊断NAFLD的ROC曲线下面积、最佳阈值及敏感度、特异度、误诊率、漏诊率分别为0.73(P0.01)、134.9(ng/d L)、75.0%、72.5%、27.5%、25.0%。结论 NAFLD患者血清铁和铁蛋白水平均出现升高,与超声诊断结果具有明显相关性。
[Abstract]:Objective to investigate the relationship between serum iron ion and serum ferritin concentration in (nonalcoholic fatty liver disease (NAFLD) diagnosed by ultrasonic imaging. Methods 40 cases of non-alcoholic fatty liver disease diagnosed by ultrasonic imaging were used as case group and 40 cases of non-alcoholic fatty liver disease as normal control group. The concentrations of serum iron and serum ferritin were detected by atomic absorption spectrometry and radioimmunoassay, respectively. Results the serum iron and ferritin levels in the case group [(105.17 卤24.52) 渭 g / d / L, (146.57 卤68.28) ng/d / L] were significantly higher than those in the control group [(85.45 卤26.84) 渭 g / d / L, (90.58 卤49.71) ng/d / L] (P0.01). The area under the curve, the optimum threshold and sensitivity, the specificity, the misdiagnosis rate and the missed diagnosis rate were 0.69 (P0.01), 123.5 (渭 g / d L) and 82.560% (渭 g / d L), respectively. The area under the curve, the optimal threshold and sensitivity, the specificity, the misdiagnosis rate and the missed diagnosis rate were 0.69 (P0.01), 123.5 (渭 g / d L) and 82.5% (渭 g / d L), respectively. The area under the ROC curve, the best threshold and sensitivity, the specificity, the misdiagnosis rate and the missed diagnosis rate were 0.73 (P0.01), 134.9 (ng/d L) and 72.5% (ng/d L), respectively. Conclusion the serum iron and ferritin levels in patients with NAFLD were increased, which was significantly correlated with the results of ultrasound diagnosis.
【作者单位】：首都医科大学宣武医院超声诊断科;首都医科大学第一临床学院;
【基金】：首都医科大学本科生科研创新课题资助(xsky2013072)
【分类号】：R575.5

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