聚乙二醇溶液分次与早晨单次口服对肠道准备有效性与安全性的Meta分析

发布时间：2018-08-11 19:21

【摘要】：目的系统评价分次口服与早晨单次口服聚乙二醇溶液(PEG)在肠镜检查前行肠道准备的有效性和安全性。方法检索MEDLINE、PubMed、Cochrane Central Register of Controlled TrialsDatabase of Systematic Reviews、CINAHL、EMBASE、WanFang Data及CNKI数据库,收集分次口服及早晨单次口服PEG进行肠道准备的相关随机对照试验研究,并根据纳入标准和排除标准进行文献筛选,同时提取资料数据及对文献质量进行评估,采用Stata12.0软件进行Meta分析。结果共纳入6篇文献,共1258例患者。Meta分析结果显示,在肠道清洁率、息肉发现率及腺瘤发现率方面,分次口服组与早晨单次口服组相差不大。而在不良反应包括呕吐、腹痛、腹胀、头痛、睡眠缺失等发生率方面,分次口服组与早晨单次口服组对比,其发生率相似;而在恶心发生率方面,分次口服组发生率少于早晨口服组。结论在肠道准备中,分次口服PEG与检查肠镜当天早晨单次口服PEG相比,两者在有效性上相差不大,但在安全性上,分次口服略优于早晨单次口服。
[Abstract]:Objective to evaluate the efficacy and safety of (PEG) before enteroscopy. Methods the database of MEDLINE Central Register of Controlled TrialsDatabase of Systematic Reviews of Cochrane Central Register of Controlled TrialsDatabase of Systematic reviews and CNKI were searched, and the relevant randomized controlled trial studies were collected for intestinal preparation by oral administration and single oral administration of PEG in the morning, and the literature was screened according to the inclusion criteria and exclusion criteria. At the same time, the data were extracted and the quality of literature was evaluated. Meta analysis was carried out with Stata12.0 software. Results A total of 1258 patients. Meta-analysis showed that the intestinal cleaning rate, polyp detection rate and adenoma detection rate in the oral group were not significantly different from those in the single oral group in the morning. The incidence of adverse effects including vomiting, abdominal pain, abdominal distension, headache, sleep loss and so on was similar to that of the single oral group in the morning, while the incidence of nausea was similar. The incidence of oral administration was less than that of morning oral group. Conclusion in intestinal preparation, the efficacy of oral PEG in the morning of enteroscopy is not significantly different from that of single oral PEG in the morning of endoscopy, but the safety is slightly better than that of single oral in the morning.
【作者单位】：广西医科大学第一附属医院老年病学消化内科;
【基金】：国家自然科学基金(81660093)
【分类号】：R574

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