乌司他丁对溃疡性结肠炎患者血清炎症因子的影响

发布时间：2018-08-13 08:35

【摘要】：目的:观察乌司他丁对溃疡性结肠炎患者血清炎症因子的影响。方法:60例溃疡性结肠炎患者随机均分为观察组和试验组,同时选择20名健康志愿者作为健康对照组。试验组患者给予营养补充、维持水电解质平衡、5-氨基水杨酸等常规治疗;观察组患者在试验组治疗基础上加用乌司他丁20万U静脉注射,q12h。两组患者均以7 d为1个疗程,连续治疗2个疗程。观察两组患者治疗前后肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)、IL-8、C反应蛋白(CRP)水平及结肠髓过氧化物酶(MPO)活性和病情活动指数(CAI)评分,并与健康对照组进行比较,同时记录不良反应发生情况。结果:两组患者治疗前后TNF-α、IL-1β、IL-8、CRP水平及MPO活性显著高于健康对照组,差异均有统计学意义(P0.05)。治疗后,两组患者TNF-α、IL-1β水平和MPO活性、CAI评分及观察组IL-8、CRP水平显著低于同组治疗前,且观察组TNF-α、IL-8、CRP水平显著低于试验组,差异均有统计学意义(P0.05)。两组患者均未见明显不良反应发生。结论:在常规治疗基础上加用乌司他丁可有效抑制溃疡性结肠炎患者多种血清炎症因子的表达,缓解结肠炎症反应与损伤,且安全性较好。
[Abstract]:Objective: to observe the effect of ulinastatin on serum inflammatory factors in patients with ulcerative colitis. Methods 60 patients with ulcerative colitis were randomly divided into the observation group and the experimental group, and 20 healthy volunteers were selected as the healthy control group. The patients in the experimental group were given nutritional supplement to maintain the balance of water and electrolyte, and the patients in the observation group were treated with ulinastatin 200000 U intravenously for 12 h. The patients in both groups were treated with 7 days as a course of treatment and 2 consecutive courses of treatment. Tumor necrosis factor 伪 (TNF- 伪), interleukin-1 尾 (IL-1 尾) IL-8 C-reactive protein (CRP), myeloperoxidase (MPO) activity and disease activity index (CAI) were measured before and after treatment in the two groups. Adverse reactions were also recorded. Results: before and after treatment, the levels of TNF- 伪 IL-1 尾 IL-8 and the activity of MPO in the two groups were significantly higher than those in the healthy control group (P0.05). After treatment, the levels of TNF- 伪 IL-1 尾 and MPO activity were significantly lower in the observation group than before treatment, and the levels of TNF- 伪 and IL-8 in the observation group were significantly lower than those in the experimental group (P0.05). No significant adverse reactions occurred in both groups. Conclusion: Ulinastatin on the basis of routine therapy can effectively inhibit the expression of various serum inflammatory factors in patients with ulcerative colitis and relieve the reaction and injury of colitis.
【作者单位】：武汉科技大学附属普仁医院;
【分类号】：R574.62

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