无症状人群结直肠息肉检出情况及危险因素分析

发布时间：2018-08-16 17:33

【摘要】：目的探讨不同病理类型结直肠息肉在无症状人群中的检出情况及相关危险因素。方法收集我院2013-2016年接受结直肠镜检查但无临床症状的体检者702例的临床资料[年龄、性别、体质量指数(BMI)、吸烟情况、一级亲属结直肠癌家族史、2型糖尿病及胆囊结石病史]和肠镜结果。根据肠镜结果和息肉病理类型分组,分析不同病理类型息肉的检出情况及危险因素。结果腺瘤、增生性息肉(hyperplasic polyp,HP)、广基锯齿状腺瘤/息肉、传统锯齿状腺瘤、炎性息肉的检出率分别为14.0%(98/702)、8.8%(62/702)、0.6%(4/702)、0.1%(1/702)、0.9%(6/702),进展期腺瘤的检出率为2.7%(19/702)。年龄≥50岁(50~60岁:OR=1.712,95%CI=1.048~2.798,P=0.032;≥60岁:OR=2.151,95%CI=1.146~4.036,P=0.017)、吸烟≥400支/年(OR=1.866,95%CI=1.120~3.109,P=0.017)、一级亲属结直肠癌家族史(OR=1.853,95%CI=1.038~3.310,P=0.037)是腺瘤的独立危险因素;BMI≥24.0 kg/m~2(OR=3.150,95%CI=1.069~9.280,P=0.037)、2型糖尿病(OR=4.430,95%CI=1.248~15.721,P=0.021)是进展期腺瘤的独立危险因素;吸烟≥400支/年(OR=2.200,95%CI=1.203~4.024,P=0.010)是HP唯一的独立危险因素。结论腺瘤及HP是无症状人群结直肠息肉的主要病理类型。吸烟、50岁以上、一级亲属结直肠癌家族史是腺瘤的危险因素,若同时合并2型糖尿病或体质量超重则增加进展期腺瘤的风险。吸烟也是HP的危险因素,且对HP的促进作用可能更显著。
[Abstract]:Objective to investigate the detection and risk factors of colorectal polyps in asymptomatic population. Methods the clinical data of 702 patients who underwent colonoscopy but without clinical symptoms in our hospital from 2013 to 2016 were collected [age, sex, body mass index (BMI),) smoking status]. Familial history of first degree relatives with type 2 diabetes mellitus and gallstone. According to the results of colonoscopy and pathological types of polyps, the detection and risk factors of polyps of different pathological types were analyzed. Results the detection rates of adenomas, hyperplasic polyps, wide-base serrated adenomas / polyps, traditional serrated adenomas and inflammatory polyps were 14.0% (98 / 702) and 0.8% (62 / 702) respectively. The detection rates of advanced adenomas were 0.9% (1 / 702) and 2.7% (19 / 702), respectively. 骞撮緞鈮，

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