血清Ghrelin水平与慢性萎缩性胃炎的关系

发布时间：2018-08-20 14:58

【摘要】：目的与意义:检测血清Ghrelin在慢性非萎缩性胃炎及慢性萎缩性胃炎中的水平,探讨血清Ghrelin在不同萎缩程度及不同萎缩部位慢性萎缩性胃炎中的变化规律及意义,以期为慢性萎缩性胃炎的筛查与初步诊断提供更多的依据。研究方法:以2016年3月至2016年12月于我院消化内镜科门诊就诊,并接受电子胃镜检查及血清Ghrelin水平测定的慢性胃炎患者作为研究对象。根据电子胃镜检查及病理活检结果,分组如下:慢性非萎缩性胃炎组、慢性萎缩性胃炎组;其中慢性萎缩性胃炎组按照萎缩程度不同可分为轻度慢性萎缩性胃炎组、中度慢性萎缩性胃炎组、重度慢性萎缩性胃炎组三组;按照萎缩部位不同可分为全胃萎缩性胃炎组、胃窦萎缩性胃炎组两组。收集患者血清,采用酶联免疫吸附法(Enzyme-linked immunoadsorbent assay,ELISA)检测慢性胃炎患者的空腹血清Ghrelin水平。结果:1.慢性萎缩性胃炎组患者的血清Ghrelin水平低于慢性非萎缩性胃炎组,且慢性萎缩性胃炎各亚组的血清Ghrelin水平均较慢性非萎缩性胃炎组低,差异具有统计学意义(P0.05)。2.轻度慢性萎缩性胃炎组、中度慢性萎缩性胃炎组、重度慢性萎缩性胃炎组的血清Ghrelin水平不同,且血清Ghrelin水平随着胃黏膜萎缩程度的加重而降低,各组间差异均具有统计学意义(P0.05);血清Ghrelin水平与胃黏膜萎缩程度有相关性,且呈负相关(r-0.593,P0.05)。3.慢性萎缩性胃炎组内,全胃萎缩性胃炎组患者的血清Ghrelin水平低于胃窦萎缩性胃炎组,且均较慢性非萎缩性胃炎组的血清Ghrelin水平低,差异具有统计学意义(P0.05)。结论:血清Ghrelin水平与胃黏膜的萎缩有关,且与萎缩严重程度呈负相关,受胃黏膜萎缩部位的影响,全胃萎缩者低于胃窦萎缩者,因此血清Ghrelin可作为慢性萎缩性胃炎的筛查和初步诊断的辅助指标之一。
[Abstract]:Objective and significance: to detect the level of serum Ghrelin in chronic non-atrophic gastritis and chronic atrophic gastritis, and to explore the changes and significance of serum Ghrelin in chronic atrophic gastritis with different atrophy degrees and different atrophy sites. In order to provide more evidence for screening and preliminary diagnosis of chronic atrophic gastritis. Methods: from March 2016 to December 2016, patients with chronic gastritis treated in our hospital from March 2016 to December 2016 were examined by electronic gastroscopy and serum Ghrelin level. According to the results of electronic gastroscopy and pathological biopsy, the groups were as follows: chronic non-atrophic gastritis group, chronic atrophic gastritis group, and chronic atrophic gastritis group can be divided into mild chronic atrophic gastritis group according to the degree of atrophy. Moderate chronic atrophic gastritis group, severe chronic atrophic gastritis group three groups, according to the atrophy position different can be divided into total gastric atrophic gastritis group, antral atrophic gastritis group two groups. The fasting serum Ghrelin levels in patients with chronic gastritis were measured by Enzyme-linked immunoadsorbent Elisa. The result is 1: 1. The serum Ghrelin level of chronic atrophic gastritis group was lower than that of chronic non-atrophic gastritis group, and the serum Ghrelin level of chronic atrophic gastritis group was lower than that of chronic non-atrophic gastritis group (P0.05). The serum Ghrelin levels were different in mild chronic atrophic gastritis, moderate chronic atrophic gastritis and severe chronic atrophic gastritis, and the serum Ghrelin levels decreased with the severity of gastric mucosal atrophy. The serum Ghrelin level was correlated with the degree of gastric mucosal atrophy, and was negatively correlated (r -0.593P 0.05). 3. In chronic atrophic gastritis group, the serum Ghrelin level of patients with total atrophic gastritis group was lower than that of antral atrophic gastritis group, and the serum Ghrelin level was lower than that of chronic non-atrophic gastritis group (P0.05). Conclusion: the level of serum Ghrelin is related to gastric mucosal atrophy and negatively correlated with the severity of atrophy. Affected by the site of gastric mucosal atrophy, the total gastric atrophy is lower than that of antral atrophy. Therefore, serum Ghrelin can be used as an auxiliary index for screening and preliminary diagnosis of chronic atrophic gastritis.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R573.32

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