磁共振弹性成像对肝纤维化分级诊断价值的Meta分析
发布时间：2018-08-21 10:46
【摘要】：目的:采用Meta分析方法探讨磁共振弹性成像(MRE)对肝纤维化分级的诊断效能及临床应用价值,为临床对肝纤维化的治疗提供依据。方法:搜索2017年2月2日前国内外公开发表的MRE诊断肝纤维化分级的中文和英文文献。纳入数据库包括PubMed、EMBase、Web of Science、Cochrane Library、中国知网、中国生物医学文献数据库、维普数据库和万方数据库,并辅以手工检索,按照预先纳入及排除标准进行筛选,提取资料,采据QUADAS-2工具进行文献质量评价,采用Stata软件分别对F0 vs F1-F4组、F0-F1 vs F2-F4组、F0-F2 vs F3-F4组和F0-F3 vs F4组MRE对肝纤维化分期诊断的敏感度(SEN)、特异度(SPE)、诊断比值比(DOR)、阳性似然比(+LR)和阴性似然比(-LR)进行合并计算及异质性检验,绘制分层综合受试者工作特征曲线(HSROC),计算曲线下面积(AUROC)。结果:共检索出1 332篇文献,最后纳入22篇,其中英文21篇,中文1篇。Meta分析,SEN合并、SPE合并、+LR合并、-LR合并、DOR合并和AUROC,F0 vs F1-F4组分别为88.8%(85.0%~91.7%)、95.9%(91.5%~98.0%)、21.435(10.215~44.979)、0.117(0.086~0.159)、183.187(72.533~462.650)和0.96(0.94~0.98),F0-F1 vs F2-F4组分别为93.3%(89.2%~35.9%)、94.1%(90.2%~96.5%)、15.839(9.344~26.848)、0.072(0.044~0.117)、221.224(100.980~484.648)和0.98(0.96~0.99),F0-F2 vs F3-F4组分别为92.9%(88.9%~95.5%)、94.6%(91.2%~96.8%)、17.348(10.496~28.671)、0.075(0.048~0.119)、230.434(111.482~476.317)和0.98(0.96~0.99),F0-F3 vs F4组分别为97.7%(93.0%~99.3%)、93.2%(90.3%~95.2%)、14.337(9.910~20.742)、0.025(0.008~0.075)、580.405(144.871~2 325.307)和0.98(0.96~0.99)。结论:MRE作为一种新型和无创的影像检查手段,对不同分期肝纤维化均具有较高诊断价值,可为临床肝纤维化的精准治疗提供可靠参考。
[Abstract]:Objective: to investigate the diagnostic efficacy and clinical application value of magnetic resonance elastography (MRE) in the classification of hepatic fibrosis by Meta analysis, so as to provide the basis for clinical treatment of hepatic fibrosis. Methods: Chinese and English literatures on MRE diagnosis of hepatic fibrosis were published at home and abroad before February 2, 2017. Included in the database are PubMeden's EMBaseof Science of Science Cochrane Library, China KnowledgeNet, Chinese Biomedical Literature Database, Weip Database and Wanfang Database, supplemented by manual retrieval, screening according to pre-inclusion and exclusion criteria, and extracting data. According to the QUADAS-2 tool to evaluate the literature quality, The sensitivity of MRE in F0 vs F1-F4 group, F0-F1 vs F2-F4 group, F0-F2 vs F3-F4 group and F0-F3 vs F4 group in the diagnosis of hepatic fibrosis staging was evaluated by Stata software. The ratio of (SEN), specificity to (SPE), was higher than that of (DOR), positive likelihood ratio (LR) and negative likelihood ratio (-LR). Drawing stratified synthetic subjects' operating characteristic Curve (HSROC), to calculate area (AUROC). Under Curve Results: a total of 1 332 articles were retrieved, and 22 articles were included, of which 21 were in Chinese and English. 涓枃1绡，
本文编号：2195463
[Abstract]:Objective: to investigate the diagnostic efficacy and clinical application value of magnetic resonance elastography (MRE) in the classification of hepatic fibrosis by Meta analysis, so as to provide the basis for clinical treatment of hepatic fibrosis. Methods: Chinese and English literatures on MRE diagnosis of hepatic fibrosis were published at home and abroad before February 2, 2017. Included in the database are PubMeden's EMBaseof Science of Science Cochrane Library, China KnowledgeNet, Chinese Biomedical Literature Database, Weip Database and Wanfang Database, supplemented by manual retrieval, screening according to pre-inclusion and exclusion criteria, and extracting data. According to the QUADAS-2 tool to evaluate the literature quality, The sensitivity of MRE in F0 vs F1-F4 group, F0-F1 vs F2-F4 group, F0-F2 vs F3-F4 group and F0-F3 vs F4 group in the diagnosis of hepatic fibrosis staging was evaluated by Stata software. The ratio of (SEN), specificity to (SPE), was higher than that of (DOR), positive likelihood ratio (LR) and negative likelihood ratio (-LR). Drawing stratified synthetic subjects' operating characteristic Curve (HSROC), to calculate area (AUROC). Under Curve Results: a total of 1 332 articles were retrieved, and 22 articles were included, of which 21 were in Chinese and English. 涓枃1绡，
本文编号：2195463
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