2型糖尿病合并非酒精性脂肪肝围绝经期女性血浆ox-LDL的研究

发布时间：2018-08-26 13:23

【摘要】：目的研究2型糖尿病合并非酒精性脂肪肝(T2DM+NAFLD)围绝经期女性血浆氧化低密度脂蛋白(ox-LDL)水平及相关因素分析。方法选择2013年9月至2014年2月住院的年龄45~60岁围绝经期女性,其中T2DM患者50例,T2DM+NAFLD患者41例,及来自同期体检中心围绝经期女性健康对照(NC)者40例,检测血ox-LDL水平及血糖、血脂、肝功能和肾功能等指标,并分析ox-LDL与各项指标的相关性。结果围绝经期T2DM+NAFLD患者ox-LDL、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、体质量指数(BMI)、尿酸(UA)和丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、γ-谷氨酰转肽酶(γ-GT)明显高于T2DM患者及NC者,而高密度脂蛋白(HDL-C)水平明显较低(P0.05)。多元逐步回归分析显示,TG、HDLc、UA是ox-LDL水平的独立相关因素(P0.05)。结论 T2DM+NAFLD的围绝经期女性患者血浆ox-LDL升高,提示氧化应激可能是围绝经期T2DM+NAFLD的重要病理生理因素。
[Abstract]:Objective to study the plasma levels of oxidized low density lipoprotein (ox-LDL) and related factors in type 2 diabetes mellitus women with non alcoholic fatty liver (T2DM NAFLD). Methods A total of 45 postmenopausal women aged 45 to 60 were enrolled from September 2013 to February 2014. Among them, 50 T2DM patients with T2DM NAFLD, and 40 healthy controls (NC) from the same physical examination center, were enrolled in this study. The blood ox-LDL levels and blood glucose levels were measured. Serum lipids, liver function and renal function were analyzed, and the correlation between ox-LDL and various indexes was analyzed. Results ox-LDL, triglyceride (TG), low density lipoprotein cholesterol (LDL-C), body mass index (BMI),) (UA) and (ALT), aspartate aminotransferase (AST), 纬 -glutamyl transpeptidase (纬 -GT) in peri-menopausal T2DM NAFLD patients were significantly higher than those in T2DM patients and NC patients. The level of high density lipoprotein (HDL-C) was significantly lower (P0.05). Multiple stepwise regression analysis showed that HDLC UA was an independent correlation factor of ox-LDL level (P 0.05). Conclusion the increase of plasma ox-LDL in peri-menopausal women with T2DM NAFLD suggests that oxidative stress may be an important pathophysiological factor of peri-menopausal T2DM NAFLD.
【作者单位】：承德医学院附属医院内分泌科;
【基金】：河北省卫生厅科研基金项目(20130022)
【分类号】：R587.2;R575

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