评价与分析复方大承气汤联合西药治疗重症急性胰腺炎疗效与安全性

发布时间：2018-09-13 14:48

【摘要】：目的:评价与分析复方大承气汤联合西药治疗重症急性胰腺炎疗效与安全性。方法:选择本院2010年5月—2013年5月所收治的80例重症急性胰腺炎患者,按照随机数字表法分组为观察组和对照组。对照组:采用采用西药乌司他丁治疗。观察组:乌司他丁联合复方大承气汤治疗。观察两组患者治疗前、后病情评分、实验室指标恢复时间及临床症状、体征恢复时间、临床疗效、不良反应情况。结果:治疗前,两组患者APACHEII评分比较(P0.05);治疗3d、7 d、14 d后,观察组APACHEII评分分别为为(6.98±1.23)分、(5.54±1.01)分、(4.47±0.69)分,对照组则分别为(7.01±1.21)分、(6.28±1.12)分、(5.53±0.78)分;与治疗前比较(P0.05);治疗3 d后,两组APACHEII评分比较(P0.05);治疗5 d和10 d后,两组APACHEII评分比较(P0.05)。两组患者实验室指标恢复时间及临床症状、体征恢复时间、临床疗效、不良反应比较(P0.05)。结论:相比单纯西药乌司他丁来说,采用乌司他丁联合复方大承气汤治疗重症急性胰腺炎具有更好的效果,且不良反应少。
[Abstract]:Objective: to evaluate and analyze the efficacy and safety of compound Dachengqi decoction combined with western medicine in the treatment of severe acute pancreatitis. Methods: 80 patients with severe acute pancreatitis admitted in our hospital from May 2010 to May 2013 were divided into observation group and control group according to random number table method. The control group was treated with ulinastatin. Observation group: ulinastatin combined with compound Dachengqi decoction treatment. Before and after treatment, the scores, the recovery time of laboratory indexes and clinical symptoms, the recovery time of physical signs, the clinical efficacy and adverse reactions were observed. Results: before treatment, the APACHEII scores of the two groups were compared (P0.05), and the APACHEII scores of the observation group were (6.98 卤1.23), (5.54 卤1.01), (4.47 卤0.69), respectively, and those of the control group were (7.01 卤1.21), (6.28 卤1.12), (5.53 卤0.78), respectively, after 3 days of treatment (P0.05). The APACHEII scores of the two groups were compared (P0.05), and after 5 days and 10 days of treatment, the APACHEII scores of the two groups were compared (P0.05). The recovery time of laboratory indexes and clinical symptoms, physical signs, clinical efficacy and adverse reactions were compared between the two groups (P0.05). Conclusion: ulinastatin combined with compound Dachengqi decoction is more effective and has less adverse reactions than ulinastatin in the treatment of severe acute pancreatitis.
【作者单位】：富阳市人民医院消化内科;
【分类号】：R576

【参考文献】