肝水解肽与肝水解肽联合丹参川穹嗪对青海地区肝硬化患者疗效的分析

发布时间：2018-09-18 15:54

【摘要】：目的:通过对比研究单用肝水解肽与肝水解肽联合丹参川穹嗪对治疗青海地区肝硬化患者的疗效,明确二者有无统计学意义,从而更好地指导临床用药。方法:从2014年5月-2016年2月青海大学附属医院肝胆胰科确诊并住院治疗的肝硬化病人中选取30例作为A组,记录其性别、年龄、族别及肝功能(Child-Pugh)分级等指标,作为配对条件。选取符合纳入标准、排除标准以及满足配对条件的肝硬化病人30例作为B组,确保能与A组30例严格配对。A组单用肝水解肽100mg,静滴,1次/日,进行治疗,B组应用肝水解肽100mg加丹参川穹嗪10ml,静滴,1次/日进行治疗。分别观察并记录治疗前、治疗10天、治疗20天后两组所有肝硬化患者的肝功能生化指标。用SPSS 17.0录入数据并进行统计学分析,由于该样本量较小(30对),配对样本差值经正态性检验,不服从正态分布,呈偏态分布,故该资料用中位数,四分位数间距即M,(QL-QU)表示,组间比较用秩和检验,以a=0.05为显著性检验水准。结果:治疗10天时,经秩和检验五项指标比较得出的Z值分别为:ALT,1.214;AST,0.508;ALP,1.080;GGT,0.463;CHE,1.512;P值分别为:ALT,0.225;AST,0.611;ALT,0.280;GGT,0.644;CHE,0.131。每项指标P0.05。治疗20天时,经秩和检验五项指标比较得出的Z值分别为:ALT,-2.220;AST,-0.035;ALP,-2.494;GGT,-2.403;CHE,-2.464;P值分别为:ALT,0.026;AST,0.738;ALT,0.013;GGT,0.016;CHE,0.008。其中,ALT、ALP、GGT、CHE指标P0.05,AST指标P0.05。结论:通过单用肝水解肽与肝水解肽联合丹参川穹嗪对治疗青海地区60例肝硬化患者的疗效对比分析,在治疗10天时,两组所观察指标无明显差异,结果无统计学意义;在治疗20天时,两组所观察的五项指标中有四项有明显差异,结果有统计学意义,仅AST一项未见明显差异,结果无统计学意义。
[Abstract]:Objective: to compare the efficacy of liver hydrolysate peptide and Danshen daizizine in the treatment of liver cirrhosis in Qinghai area, and to find out whether there is statistical significance between them. Methods: from May 2014 to February 2016, 30 patients with liver cirrhosis diagnosed and hospitalized in Department of Hepatobiliary Pancreatology, affiliated Hospital of Qinghai University were selected as group A, and their sex, age, ethnicity and Child-Pugh grading were recorded as matched conditions. Thirty cirrhotic patients who met the inclusion criteria, exclusion criteria and matching conditions were selected as group B to ensure that only 100 mg of hepatic hydrolysate was given intravenously to group A and 30 cases of group A were strictly matched. Group B was treated with liver hydrolysate peptide 100mg and danshen dachonosin 10 ml once a day. The biochemical indexes of liver function were observed and recorded before, 10 days and 20 days after treatment. The data were inputted by SPSS 17.0 and analyzed statistically. Because the sample size was small (30 pairs), the difference value of matched sample was tested by normality, and the data was skewed from normal distribution. Therefore, the data was represented by median, quartile spacing, I. E. M, (QL-QU). The rank sum test was used in the comparison between groups, with a significant test level of 0.05. Results: after 10 days of treatment, the Z values of the five indexes by rank sum test were as follows: 1: ALT 1.214A AST 0.508U ALPU 1.080 GGT0.463CHE1 512P = 0. 225m AST 0.611ALT0.280GGT0.644CHE 0.131. Each index (P0.05). After 20 days of treatment, the Z values compared with the five indexes of rank sum test were as follows: 1 / ALT ~ (-2.220) AST ~ (-0.035) ~ (-2.494) ~ (-2.404) GGT-2.404 ~ (th) Chem -2.464 (P = 0. 026) and 0. 738% ALT ~ (0.013) GGT ~ (0.016) Chem 0.008, respectively. The GGTCHE index P0.05and AST P0.05. Conclusion: there was no significant difference between the two groups in the treatment of 60 patients with liver cirrhosis in Qinghai area after 10 days of treatment, and there was no significant difference between the two groups. After 20 days of treatment, four of the five indexes observed in the two groups were significantly different, the results were statistically significant, only one item of AST had no significant difference, but the results were not statistically significant.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R575.2

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