他汀类对重症急性胰腺炎患者肾功能预后的影响

发布时间：2018-10-11 11:34

【摘要】：目的探讨他汀类对重症急性胰腺炎患者肾功能预后的影响。方法选择2014年6月至2016年6月收治的重症急性胰腺炎(SAP)伴发急性肾损伤(AKI)患者57例,采用数字法随机分为两组,其中他汀组27例,对照组30例。观察他汀组患者尿、血淀粉酶(AMY)、尿素氮(BUN)、肌酐(Cr)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL)及高密度脂蛋白胆固醇(HDL)治疗前后含量变化,并与对照组比较有无差异。结果治疗前两组的AMY、BUN、Cr、TC、TG、LDL及HDL差异均无统计学意义。治疗后两组除了TG差异无统计学意义,AMY、BUN、Cr、TC及LDL均显著下降以及HDL显著升高,差异有统计学意义(P0.05)。他汀组对AMY、BUN、Cr的降低作用在治疗后的7和14 d均显著优于对照组(P0.05)。同时对TC及LDL的降低作用以及HDL的升高作用在治疗后的14 d均优于对照组(P0.05)。结论他汀类对重症急性胰腺炎患者的肾功能有一定的保护作用,其机制可能与抑制羟甲基戊二酸单酰辅酶A、清除氧自由基等有关。
[Abstract]:Objective to investigate the effect of statins on renal function prognosis in patients with severe acute pancreatitis. Methods from June 2014 to June 2016, 57 patients with severe acute pancreatitis (SAP) complicated with acute renal injury (AKI) were randomly divided into two groups: statin group (n = 27) and control group (n = 30). Urine, serum amylase (AMY), urea nitrogen, (BUN), creatinine, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL) and high density lipoprotein cholesterol (HDL) were observed before and after treatment in statins group. Results there was no significant difference in AMY,BUN,Cr,TC,TG,LDL and HDL between the two groups before treatment. After treatment, there was no significant difference between the two groups except TG, AMY,BUN,Cr,TC and LDL were significantly decreased and HDL significantly increased, the difference was statistically significant (P0.05). The decrease of AMY,BUN,Cr in statins group was significantly better than that in control group at 7 and 14 days after treatment (P0.05). At the same time, the decrease of TC and LDL and the increase of HDL were better than those of the control group on the 14th day after treatment (P0.05). Conclusion statins have protective effect on renal function in patients with severe acute pancreatitis. The mechanism may be related to inhibition of hydroxymethyl glutaryl coenzyme A and scavenging of oxygen free radicals.
【作者单位】：海南医学院第二附属医院;
【基金】：海南省自然科学基金资助项目(编号:812175)
【分类号】：R576

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