臌胀片在代偿期丙型肝炎肝硬化抗病毒治疗中的应用

发布时间：2018-10-14 13:21

【摘要】：目的评价臌胀片对代偿期丙型肝炎肝硬化抗病毒疗效的影响。方法将80例代偿期丙型肝炎肝硬化患者随机分为观察组和对照组各40例,均予聚乙二醇干扰素α-2a、利巴韦林抗病毒治疗,观察组另服臌胀片,治疗24周,随访24周,比较两组病毒学应答率、Child-Pugh评分、肝功能、血常规。结果治疗48周后,观察组持续应答率高于对照组(P0.05);两组治疗后各时点Child-Pugh评分较治疗前明显降低(P均0.05),且观察组较对照组降低更明显(P均0.05);治疗第24、48周,观察组肝功能指标低于对照组(P均0.05)。治疗第12、24周,观察组白细胞高于对照组(P均0.05);治疗第24周,观察组血小板高于对照组(P0.05)。结论臌胀片可提高聚乙二醇干扰素α-2a联合利巴韦林治疗代偿期丙型肝炎肝硬化抗病毒疗效,且能减轻其不良反应。
[Abstract]:Objective to evaluate the effect of tympanic tablet on antiviral effect of compensatory hepatitis C cirrhosis. Methods Eighty patients with compensatory hepatitis C cirrhosis were randomly divided into two groups: the observation group (n = 40) and the control group (n = 40). All patients were treated with peginterferon 伪 -2a and ribavirin respectively. The virological response rate, Child-Pugh score, liver function and blood routine were compared between the two groups. Results after 48 weeks of treatment, the rate of sustained response in the observation group was higher than that in the control group (P0.05), the Child-Pugh score at each time point after treatment in both groups was significantly lower than that before treatment (P 0.05), and the Child-Pugh score in the observation group was significantly lower than that in the control group (P 0.05). The indexes of liver function in the observation group were lower than those in the control group (P 0.05). At the 24th week of treatment, the white blood cells in the observation group were higher than those in the control group (P 0.05), and the platelets in the observation group were higher than those in the control group at the 24th week (P0.05). Conclusion the combination of pegyleneglycol interferon 伪-2a and ribavirin can improve the antiviral effect and alleviate the adverse reactions of the patients with compensatory hepatitis C cirrhosis.
【作者单位】： 河南省中医药研究院附属医院;
【基金】：河南省中医药继承与创新专项(072103810804)
【分类号】：R512.63;R575.2
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本文编号：2270583