血清降钙素原与血清淀粉样蛋白A和白细胞介素-8诊断肝硬化腹水感染的研究
发布时间：2018-10-14 13:30
【摘要】：目的探讨血清降钙素原(PCT)、血清淀粉样蛋白A(SAA)、白细胞介素-8(IL-8)诊断肝硬化腹水感染的临床价值研究,为肝硬化腹水感染的诊断提供参考。方法选取医院2015年1月-2016年12月住院治疗的肝硬化腹水患者100例,根据患者是否发生腹水感染分为感染组32例与无感染组68例,入院后穿刺抽取腹水进行细菌培养,抽取外周静脉血检测血清PCT、SAA、IL-8。结果 100例患者腹水培养阳性32例,感染率32.00%,32例共培养出病原菌35株,其中革兰阳性菌23株占65.71%,革兰阴性菌12株占34.29%。感染组患者血清PCT、SAA、IL-8分别为(5.22±1.25)ng/ml、(35.51±8.12)mg/L、(18.49±3.40)pg/ml显著高于无感染组(0.17±0.18)ng/ml、(4.19±0.27)mg/L、(10.20±2.34)pg/ml(P0.05);以腹水细菌培养阳性为金标准,血清PCT、SAA、IL-8用于诊断腹水感染的灵敏度分别为96.88%、93.75%、87.50%,特异度分别为88.24%、79.41%、82.35%,曲线下面积为0.924、0.912、0.903,准确率为91.00%、84.00%、84.00%。结论血清PCT、SAA、IL-8在肝硬化患者腹水感染时会出现升高,用于腹水感染的辅助诊断有较高的灵敏度及特异度,对临床无明显腹水感染症状的患者如存在血清PCT、SAA、IL-8的升高,建议进行早期干预治疗。
[Abstract]:Objective to investigate the clinical value of serum procalcitonin (PCT), (PCT),) serum amyloid protein A (SAA), interleukin-8 (IL-8) in the diagnosis of ascites infection in cirrhotic patients. Methods from January 2015 to December 2016, 100 patients with ascites due to cirrhosis were divided into infection group (32 cases) and non-infected group (68 cases). Detection of serum PCT,SAA,IL-8. in peripheral venous blood samples Results among the 100 cases, 32 cases were positive in ascites culture, and the infection rate was 32.00%. 35 strains of pathogenic bacteria were cultured, of which 23 strains were Gram-positive bacteria (65.71%), 12 strains were Gram-negative bacteria (34.29%). 鎰熸煋缁勬偅鑰呰娓匬CT,SAA,IL-8鍒嗗埆涓，
本文编号：2270606
[Abstract]:Objective to investigate the clinical value of serum procalcitonin (PCT), (PCT),) serum amyloid protein A (SAA), interleukin-8 (IL-8) in the diagnosis of ascites infection in cirrhotic patients. Methods from January 2015 to December 2016, 100 patients with ascites due to cirrhosis were divided into infection group (32 cases) and non-infected group (68 cases). Detection of serum PCT,SAA,IL-8. in peripheral venous blood samples Results among the 100 cases, 32 cases were positive in ascites culture, and the infection rate was 32.00%. 35 strains of pathogenic bacteria were cultured, of which 23 strains were Gram-positive bacteria (65.71%), 12 strains were Gram-negative bacteria (34.29%). 鎰熸煋缁勬偅鑰呰娓匬CT,SAA,IL-8鍒嗗埆涓，
本文编号：2270606
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