部分消化道疾病患者血清过敏原的临床研究

发布时间：2018-10-14 16:12

【摘要】：目的：分析慢性胃炎、肠易激综合征、肠息肉三种消化道疾病患者血清过敏原特异性IgE抗体的检测结果，探讨过敏因素与上述三种消化道疾病有无关联。 方法：选取2012年5月至2014年4月于大连医科大学附属第一医院消化内科住院患者150例。150例患者经临床确诊慢性胃炎55例，肠易激综合征35例，肠息肉60例。其中慢性胃炎诊断标准依据胃镜诊断及病理诊断，肠易激综合征诊断依据罗马Ⅲ IBS诊断标准，肠息肉的诊断依据肠镜检查和肠黏膜活检病理诊断。对照组为同一时期于我院体检的健康人150例。采用欧蒙印迹法，对消化道疾病患者及健康人进行血清20种常见过敏原特异性IgE抗体检测，分析过敏因素与上述三种消化道疾病有无关联，应用SPSS16.0软件统计分析。 结果： 1、三种消化道疾病共150例患者与对照组150例健康人共300例血清过敏原特异性IgE抗体检测结果提示：树组合、普通豚草、艾蒿、尘螨组合、屋尘、猫毛、狗上皮、蟑螂、霉菌组合、鸡蛋白、花生、黄豆、牛肉、海鱼组合、淡水鱼组合、虾及蟹的特异性IgE抗体检测结果为阳性；律草、羊肉、牛奶的特异性IgE抗体检测结果为阴性。 2、三种消化道疾病共150例患者与对照组150例健康人血清过敏原特异性IgE抗体检测结果依据浓度分类构成比比较,对照组150例健康人血清过敏原特异性IgE抗体检测结果，阴性占87.33%，特异性IgE抗体浓度达到1-2级占12.67%，特异性IgE抗体浓度≥3级占0%。患者组150例患者血清过敏原特异性IgE抗体检测结果，，阴性占42.67%，特异性IgE抗体浓度达到1-2级占34.67%，特异性IgE抗体浓度达到3级占10.67%，特异性IgE抗体浓度≥4级占12.00%。 3、三种消化道疾病共150例患者与对照组150例健康人血清过敏原特异性IgE抗体阳性率比较：150例患者血清过敏原特异性IgE抗体阳性率(57.33%）明显高于对照组150例健康人（13.33%），两者比较差异有统计学意义（P＜0.05）。血清过敏原特异性IgE抗体阳性率最高的为肠易激综合征患者，其后依次为肠息肉患者及慢性胃炎患者,以上三种消化道疾病患者血清过敏原特异性IgE抗体阳性率与对照组比较差异均有统计学意义（P＜0.05）。 4、三种消化道疾病共150例患者与对照组150例健康人血清吸入性过敏原特异性IgE抗体阳性率比较：患者组尘螨组合、狗上皮、蟑螂及树组合的血清特异性IgE抗体阳性率明显高于对照组，两者比较差异有统计学意义（P＜0.05），患者组中特异性IgE抗体阳性率最高的吸入性过敏原为尘螨组合。 5、三种消化道疾病共150例患者与对照组150例健康人血清食入性过敏原特异性IgE抗体阳性率比较：患者组蟹、海鱼组合、淡水鱼组合、鸡蛋白、虾及黄豆的血清特异性IgE抗体阳性率明显高于对照组，两者比较差异有统计学意义（P＜0.05）,患者组中特异性IgE抗体阳性率最高的食入性过敏原为蟹。 6、三种消化道疾病共150例患者不同浓度水平血清吸入性过敏原特异性IgE抗体阳性率显示：在1级-2级水平，阳性率最高的过敏原为尘螨组合，在3级水平，阳性率最高的过敏原为尘螨组合，在≥4级水平，阳性率最高的过敏原为尘螨组合。 7、三种消化道疾病共150例患者不同浓度水平血清食入性过敏原特异性IgE抗体阳性率显示：在1级-2级水平，阳性率最高的过敏原为蟹，在3级水平，阳性率最高的过敏原为海鱼组合，在≥4级水平，阳性率最高的过敏原为蟹。 8、三种消化道疾病患者血清过敏原特异性IgE抗体检测结果阳性率两两比较：肠易激综合征患者血清过敏原特异性IgE抗体阳性率高于慢性胃炎患者，两者比较差异有统计学意义（P＜0.05）。 9、不同性别患者血清过敏原特异性IgE抗体检测结果的阳性率比较：男性患者血清过敏原特异性IgE抗体阳性率为56.72%，女性患者血清过敏原特异性IgE抗体阳性率为57.83%，两者比较差异无统计学意义（P＞0.05）。 结论：慢性胃炎、肠易激综合征、肠息肉三种消化道疾病患者均具有较高的血清过敏原特异性IgE抗体检测阳性率，其中血清过敏原特异性IgE抗体检测阳性率最高的吸入性过敏原为尘螨组合,血清过敏原特异性IgE抗体检测阳性率最高的食入性过敏原为蟹，过敏因素与上述三种消化道疾病有一定关联,该研究结果为今后进一步干预治疗提供一定的依据。
[Abstract]:Objective: To study the detection results of serum allergen-specific IgE antibody in patients with chronic gastritis, irritable bowel syndrome and intestinal polyp. Methods: 150 patients were selected from May 2012 to April 2014 in the First Affiliated Hospital of Dalian Medical University. 150 patients were diagnosed with chronic gastritis in 55 cases, irritable bowel syndrome in 35 cases, intestinal polyp 6. The diagnostic criteria for chronic gastritis were based on gastroscopy and pathological diagnosis, and the diagnosis of irritable bowel syndrome was based on the criteria of diagnosis of IBS, and the diagnosis of intestinal polyps was based on enteroscopy and biopsy of intestinal mucosa. Diagnosis: The control group was the healthy people in our hospital for the same period of 15 years. In 0 cases, 20 kinds of common allergen specific IgE antibody tests were carried out in patients with digestive tract diseases and healthy people by Western blot, and the correlation between allergic factors and the three kinds of digestive tract diseases was analyzed, and SPSS1.6. 0 software statistics were applied. Analysis. Results: There were 300 serum allergen-specific IgE antibody test results in 150 patients with digestive tract diseases and 150 healthy people in control group. The specific IgE antibody detection result of the combination of mold, egg white, peanut, soybean, beef, beef, fresh water fish, shrimp and crab is positive; the specific IgE antibody of the law grass, mutton and milk is positive; The serum allergen-specific IgE antibody test results of 150 patients with digestive tract diseases and 150 healthy subjects in the control group were compared with the control group. The serum allergen-specific IgE antibody detection of 150 healthy persons in the control group was detected. Fruit and negative accounted for 87. 33%, specific IgE antibody concentration reached 1-2 level of 12.67%, specific Ig The serum allergen-specific IgE antibody test results of 150 patients in the patient group accounted for 42. 67%, the specific IgE antibody concentration reached 1-2 level (34.67%), the specific IgE antibody concentration reached Grade 3 (10.67%), the specific IgE antibody concentration was 10. 67%, the specific IgE antibody concentration was 10. 67%, the specific IgE antibody concentration was 10. 67%, the specific IgE antibody concentration was 10.67%, the specific IgE antibody concentration was 10.67%, the specific IgE antibody concentration was 10.67%, the specific IgE antibody concentration was 10.67%, the specific IgE antibody concentration was 10.67%, the specific IgE antibody concentration was 10.67%, the specific IgE antibody concentration was 10.67%, the specific IgE antibody concentration reached 3 levels. The positive rate of serum allergen-specific IgE antibody in 150 patients with digestive tract diseases was higher than that of control group 1. The positive rate of serum allergen-specific IgE antibody in 150 patients (57. 33%) was significantly higher than that in control group. In 50 healthy people (13.33%), the difference was different. There was statistical significance (P <0.05). Serum allergen-specific IgE antibody positive rate was the highest in patients with irritable bowel syndrome. The positive rates of serum allergen-specific IgE antibodies in patients with intestinal polyps and chronic gastritis were compared with those in control group. The positive rates of serum aspiration allergen-specific IgE antibodies in 150 patients with digestive tract diseases were compared with 150 healthy subjects in control group (P <0.05). The positive rate of anti-IgE antibody was significantly higher than that in the control group (P <0.05). The specific IgE antibody in the patient group A total of 150 patients with digestive tract diseases and 150 healthy subjects in the control group were compared with the control group. The positive rates of the specific IgE antibodies in serum were compared with those of 150 patients with digestive tract diseases. The positive rate of serum specific IgE antibody was significantly higher than that in the control group (P <0.05). The highest positive rate of human IgE antibody was crab. The positive rate of specific IgE antibody in serum of 150 patients with three digestive tract diseases showed that the positive rate of specific IgE antibody was 1-2 level, and the highest positive rate of allergen was the highest. In combination, the allergen with the highest positive rate at level 3 was the first group. At the level of level 1-2, the highest positive rate of allergen-specific IgE antibody was crab. Level 3, highest positive rate The positive rate of serum allergen-specific IgE antibody in patients with irritable bowel syndrome was compared: the positive rate of serum allergen-specific IgE antibody in patients with irritable bowel syndrome. The positive rate of serum allergen-specific IgE antibody in patients with chronic gastritis was significantly higher than that in patients with chronic gastritis (P <0.05).. 72%, serum allergen specific IgE antibody in female patients The positive rate was 57. 83%, and the difference was not statistically significant (P> 0.05). Conclusion: Patients with chronic gastritis, irritable bowel syndrome and intestinal polyp have higher serum allergen specific IgE antibody detection positive rate. The serum allergen-specific IgE antibody has the highest positive rate of detection positive rate, and the highest positive rate of the allergen-specific IgE antibody is the food-in allergen with the highest positive rate of detection, wherein the food-in allergen is crab, and the allergy factor is similar to the above-mentioned allergen.
【学位授予单位】：大连医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R57

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