益生菌在根除幽门螺杆菌二线治疗中的疗效
发布时间：2018-10-15 20:00
【摘要】：目的观察益生菌联合四联补救疗法作为根除幽门螺杆菌失败后二线治疗辅助方案的临床疗效。方法将165例幽门螺杆菌首次根除治疗失败且经胃镜和病理学检查证实的胃十二指肠溃疡患者随机分入3组,每组55例。预防用药组、巩固用药组分别在标准四联疗法的前后给予双歧三联活菌制剂治疗,对照组仅予标准四联疗法治疗,3组患者均给予保护胃黏膜治疗。所有患者于停药1个月后复查胃镜和~(14)C呼气试验。比较3组患者的幽门螺杆菌根除率、临床症状改善总有效率、溃疡愈合率和不良反应发生率。结果预防用药组、巩固用药组的幽门螺杆菌根除率分别为86.5%(45/52)和88.7%(47/53),均显著高于对照组的68.0%(34/50,P值均0.05);溃疡愈合率分别为88.5%(46/52)和88.7%(47/53),均显著高于对照组的70.0%(35/50,P值均0.05);不良反应率分别为11.5%(6/52)和11.3%(6/53),均显著低于对照组的30.0%(15/50,P值均0.05)。预防用药组与巩固用药组间的幽门螺杆菌根除率、溃疡愈合率和不良反应发生率,以及3组间的临床症状改善总有效率的差异均无统计学意义(P值均0.05)。结论两种含益生菌的四联补救疗法均能提高幽门螺杆菌首次根除治疗失败的患者的幽门螺杆菌根除率和溃疡愈合率,并能降低不良反应发生率。
[Abstract]:Objective to observe the clinical effect of probiotics combined with tetralogy as a second-line therapy for the eradication of Helicobacter pylori. Methods 165 patients with gastroduodenal ulcer confirmed by gastroscopy and pathology were randomly divided into 3 groups, 55 patients in each group. The prophylaxis group and the consolidation group were treated with bifidobacterium triplex before and after the standard tetralogy, while the control group were treated only with standard tetralogy, and the patients in the three groups were treated with gastric mucosal protection. All patients were examined with gastroscopy and 14 C breath test 1 month after withdrawal. The rate of eradication of Helicobacter pylori, the total effective rate of clinical symptom improvement, the rate of ulcer healing and the incidence of adverse reactions were compared among the three groups. Results the prophylaxis group, The eradication rate of Helicobacter pylori was 86.5% (45 / 52) and 88.7% (47 / 53), respectively, which was significantly higher than that of the control group (68.0%) (P < 0.05), the ulcer healing rate was 88.5% (46 / 52) and 88.7% (47r53), respectively, which was significantly higher than that of the control group (70.0%) (35 / 50 P = 0.05), and the adverse reaction rate was 11.5% (6/ 52) and 11.3% (653), respectively. It was significantly lower than the control group (P = 30.0%, P = 0.05). There was no significant difference in the eradication rate of Helicobacter pylori, the rate of ulcer healing and the incidence of adverse reactions, and the total effective rate of improvement of clinical symptoms between the three groups (P < 0.05). Conclusion both two probiotic tetralogy treatments can increase the rate of HP eradication and ulcer healing in patients who failed in the first eradication of Helicobacter pylori, and can reduce the incidence of adverse reactions.
【作者单位】： 上海市第八人民医院消化内科;
【分类号】：R57
[Abstract]:Objective to observe the clinical effect of probiotics combined with tetralogy as a second-line therapy for the eradication of Helicobacter pylori. Methods 165 patients with gastroduodenal ulcer confirmed by gastroscopy and pathology were randomly divided into 3 groups, 55 patients in each group. The prophylaxis group and the consolidation group were treated with bifidobacterium triplex before and after the standard tetralogy, while the control group were treated only with standard tetralogy, and the patients in the three groups were treated with gastric mucosal protection. All patients were examined with gastroscopy and 14 C breath test 1 month after withdrawal. The rate of eradication of Helicobacter pylori, the total effective rate of clinical symptom improvement, the rate of ulcer healing and the incidence of adverse reactions were compared among the three groups. Results the prophylaxis group, The eradication rate of Helicobacter pylori was 86.5% (45 / 52) and 88.7% (47 / 53), respectively, which was significantly higher than that of the control group (68.0%) (P < 0.05), the ulcer healing rate was 88.5% (46 / 52) and 88.7% (47r53), respectively, which was significantly higher than that of the control group (70.0%) (35 / 50 P = 0.05), and the adverse reaction rate was 11.5% (6/ 52) and 11.3% (653), respectively. It was significantly lower than the control group (P = 30.0%, P = 0.05). There was no significant difference in the eradication rate of Helicobacter pylori, the rate of ulcer healing and the incidence of adverse reactions, and the total effective rate of improvement of clinical symptoms between the three groups (P < 0.05). Conclusion both two probiotic tetralogy treatments can increase the rate of HP eradication and ulcer healing in patients who failed in the first eradication of Helicobacter pylori, and can reduce the incidence of adverse reactions.
【作者单位】： 上海市第八人民医院消化内科;
【分类号】：R57
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