表观遗传修饰与溃疡性结肠炎

发布时间：2018-10-20 16:23

【摘要】：背景:基于溃疡性结肠炎发病因素的研究发现,其发生、发展是一个相当复杂的过程,涉及易感性基因响应肠道微生物内环境及其他外环境因素的变化,既可引发对机体固有免疫、特异免疫的保护和耐受,又可引起慢性炎症。目的:分析近10年溃疡性结肠炎与表观遗传修饰的相关研究进展,探讨表观遗传修饰在溃疡性结肠炎疾病中的发生、发展相关性。方法:以下列检索词:溃疡性结肠炎,表观遗传,DNA甲基化,组蛋白修饰,miRNA,ulcerative colitis,epigenetic,DNA methylation,Histone modification,miRNA,检索2000年1月至2015年1月PubMed数据库及万方医学网相关文献,根据纳入排除标准,对纳入的28条文献进行归纳分析。结果与结论:溃疡性结肠炎的发病主要是易感基因与内、外环境因素相关,受表观遗传修饰的影响。表观遗传修饰主要包括DNA甲基化、组蛋白修饰、miRNA所介导的沉默。基于溃疡性结肠炎的发病因素研究表明表观遗传修饰影响基因和环境因素之间相互作用,可作用在机体先天免疫及特异性免疫,在溃疡性结肠炎的发生、发展中具有非常重要的作用。
[Abstract]:Background: based on the study of the pathogenesis factors of ulcerative colitis, it has been found that its occurrence and development is a very complex process, which involves susceptibility genes responding to changes in the internal and external environmental factors of intestinal microbes. It can not only induce innate immunity, specific immune protection and tolerance, but also cause chronic inflammation. Objective: to analyze the related research progress of ulcerative colitis and epigenetic modification in recent 10 years, and to explore the occurrence and development of epigenetic modification in ulcerative colitis. Methods: the following key words were used: ulcerative colitis, epigenetics, DNA methylation, histone modification. MiRNA,ulcerative colitis,epigenetic,DNA methylation,Histone modification,miRNA, was used to search PubMed database and Wanfang Medical Network from January 2000 to January 2015. The 28 articles of literature included are summarized and analyzed. Results & conclusion: the pathogenesis of ulcerative colitis is mainly affected by epigenetic modification. Epigenetic modification includes DNA methylation, histone modification and miRNA mediated silencing. Based on the study of pathogenesis factors of ulcerative colitis, it is shown that the interaction between epigenetic modification and environmental factors can play an important role in innate immunity and specific immunity, and in the occurrence of ulcerative colitis. Development plays a very important role.
【作者单位】：上海中医药大学上海市针灸经络研究所;上海中医药大学;
【基金】：国家重点基础研究发展计划(973计划)资助项目(2015CB554500) 国家自然科学基金(81303033) 上海市卫生系统优秀青年人才项目(XYQ2011068)~~
【分类号】：R574.62

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