乌鲁木齐市体检人群非酒精性脂肪肝与肠易激综合征样症状的相关性

发布时间：2018-10-21 20:24

【摘要】：目的:研究乌鲁木齐市健康体检人群非酒精性脂肪肝(non-alcoholic fatty liver disease,NAFLD)和正常人群中肠易激综合征(irritable bowel syndrome,IBS)样症状的检出率,以探讨二者的相互关系.方法:用单纯随机抽样方法,对乌鲁木齐市健康体检人群中NAFLD人群作为初筛,以正常人群为对照组,再对筛出的人群进行问卷调查,结合生化、腹部超声检查等相关资料,分析体检人群NAFLD及正常人群中IBS样症状的检出率,比较两者出现IBS样症状的差异.采用秩和检验、单因素和多因素logistic回归分析对NAFLD与IBS样症状进行相关性分析.结果:正常人群和NAFLD中IBS样症状检出率分别为12.5%、23.2%,两者检出率有显著差异(P0.01);NAFLD的严重程度致IBS样症状的检出率有差别(P0.05),且差别存在于轻度、中度及重度脂肪肝之间;经多因素回归分析,体质量指数、甘油三酯、脂肪肝及族别为IBS样症状最具可能性的危险因素,其OR值分别为0.918、0.855、0.525及0.316.结论:乌鲁木齐市体检人群NAFLD中IBS样症状的检出率较高,IBS样症状与NAFLD有密切关系.
[Abstract]:Objective: to study the detection rate of non-alcoholic fatty liver (non-alcoholic fatty liver disease,NAFLD) and (irritable bowel syndrome,IBS in healthy people in Urumqi. Methods: a simple random sampling method was used to screen the NAFLD population in the healthy check-up population in Urumqi, and the normal population as the control group. The selected population was investigated by questionnaire, combined with biochemical, abdominal ultrasound examination and other relevant data. The detection rate of IBS-like symptoms in NAFLD and normal population was analyzed and the difference of IBS-like symptoms between them was compared. The correlation between NAFLD and IBS like symptoms was analyzed by rank sum test and univariate and multivariate logistic regression analysis. Results: the detection rate of IBS like symptoms in normal population and NAFLD was 12.5% or 23.22.There was significant difference between the two groups (P0.01); NAFLD severity caused IBS like symptoms (P0.05), and the difference was between mild, moderate and severe fatty liver. By multivariate regression analysis, body mass index (BMI), triglyceride (TG), fatty liver and ethnic group were the most probable risk factors for IBS like symptoms. Their OR values were 0.918 ~ 0.855U 0.525 and 0.316 respectively. Conclusion: the detection rate of IBS-like symptoms in NAFLD in Urumqi is high. IBS-like symptoms are closely related to NAFLD.
【作者单位】：新疆医科大学第一附属医院消化内科新;
【分类号】：R575.5;R574.62

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