胆囊息肉样病变简易筛检工具研究
发布时间：2018-11-02 14:42
【摘要】：目的本研究拟设计一个能够有效筛检胆囊息肉病变(PLG)的简单工具,为PLG的有效管理及防治提供参考。方法采用横断面病例-对照研究设计方法,整群抽取2014年1月—8月在陕西省西安市第四军医大学第一附属医院西京医院体检中心进行健康体检且其体检信息满足本次研究要求的12 888名体检者进行问卷调查、体格检查、腹部超声检查和实验室检测。结果 12 888名体检人群中,219例被超声诊断患有PLG,患病率为1.70%;多因素条件logistic回归分析结果表明,在校正了变量间的交互作用及多重共线性后,年龄较大、甘油三酯(TG)较高和间接胆红素较高是PLG的危险因素;将这些变量纳入构建PLG的预测模型中,最终构建的预测指数为:PLG指数=13×年龄(年龄≥50,取值为1;年龄50,取值为0)+间接胆红素+TG;PLG指数在训练数据集中的受试者工作特征曲线(ROC曲线)下面积为0.622(95%CI=0.571~0.673),在验证数据集中的ROC曲线下面积为0.615(95%CI=0.562~0.660);PLG指数P25、P25~P75、P75的PLG的阳性率分别为1.0%、1.7%、2.0%,随着PLG指数的增加,PLG的阳性率随之增加(P0.001)。结论 PLG指数在增加筛检成本效益方面具有重要意义,也可为PLG的有效防治和进一步的生活方式治疗提供帮助。
[Abstract]:Objective to design a simple tool for the screening of (PLG) in gallbladder polyps, and to provide reference for the effective management and prevention of PLG. Methods A cross-sectional case-control study was used. From January to August 2014, 12 888 medical examiners were selected from Xijing Hospital, the first affiliated Hospital of Xi'an military Medical University, Shaanxi Province, and their physical examination information met the requirements of this study. Abdominal ultrasound and laboratory examination. Results among 12 888 people, the prevalence rate of PLG, was 1.70 in 219 cases diagnosed by ultrasound. The results of multivariate conditional logistic regression analysis showed that the older age, higher triglyceride (TG) and higher indirect bilirubin were risk factors for PLG after adjusting for the interaction between variables and multiple collinearity. These variables are included in the prediction model for constructing PLG, and the final prediction index is: PLG index = 13 脳 age (age 鈮，
本文编号：2306098
[Abstract]:Objective to design a simple tool for the screening of (PLG) in gallbladder polyps, and to provide reference for the effective management and prevention of PLG. Methods A cross-sectional case-control study was used. From January to August 2014, 12 888 medical examiners were selected from Xijing Hospital, the first affiliated Hospital of Xi'an military Medical University, Shaanxi Province, and their physical examination information met the requirements of this study. Abdominal ultrasound and laboratory examination. Results among 12 888 people, the prevalence rate of PLG, was 1.70 in 219 cases diagnosed by ultrasound. The results of multivariate conditional logistic regression analysis showed that the older age, higher triglyceride (TG) and higher indirect bilirubin were risk factors for PLG after adjusting for the interaction between variables and multiple collinearity. These variables are included in the prediction model for constructing PLG, and the final prediction index is: PLG index = 13 脳 age (age 鈮，
本文编号：2306098
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