低剂量聚乙二醇联合抗坏血酸方案对肠道黏膜损伤的影响

发布时间：2018-11-04 13:27

【摘要】：目的观察低剂量聚乙二醇联合抗坏血酸方案在结肠镜检查肠道准备中的效果、安全性及对肠道黏膜损伤的影响。方法选择需做结肠镜检查的患者500例,随机分为两组,实验组给予低剂量聚乙二醇联合抗坏血酸方案(A组),对照组给予磷酸钠盐方案(B组)行肠道准备。两组患者通过抽血检测血肌酐、电解质,评估其安全性。术中观察肠道清洁度,评估肠道准备效果,同时观察肠道黏膜损伤情况,并行活检、病理学检查。结果 A组患者完成肠道准备233例,完成肠镜检查226例,B组完成肠道准备238例,完成肠镜检查210例,两组患者肠道清洁度情况无明显差异(P0.05)。肠黏膜损伤及术后血肌酐、电解质紊乱等情况低剂量聚乙二醇联合抗坏血酸组均优于磷酸钠盐组,差异有统计学意义(P0.05)。结论在肠道准备效果上,两种方法都能达到检查要求,但抗坏血酸联合聚乙二醇组对肠黏膜损伤更小,且安全性更高。
[Abstract]:Objective to observe the effect of low dose polyethylene glycol (PEG) combined with ascorbic acid in colonoscopy on intestinal preparation, safety and influence on intestinal mucosal injury. Methods 500 patients who needed colonoscopy were randomly divided into two groups. The experimental group was given low dose polyethylene glycol combined with ascorbic acid regimen (group A) and the control group was given sodium phosphate regimen (group B). Blood creatinine and electrolytes were measured to evaluate the safety of the two groups. Intestinal cleanliness was observed during operation, intestinal preparation was evaluated, intestinal mucosal injury was observed, biopsy and pathological examination were performed. Results there were 233 cases of intestinal preparation, 226 cases of endoscopy in group A, 238 cases in group B and 210 cases in group B. there was no significant difference in intestinal cleanliness between the two groups (P0.05). Intestinal mucosal injury, postoperative serum creatinine, electrolyte disturbance and so on, low dose polyethylene glycol combined with ascorbic acid group were better than sodium phosphate group, the difference was statistically significant (P0.05). Conclusion both methods can meet the examination requirements in intestinal preparation, but the damage of intestinal mucosa in the combination of ascorbic acid and polyethylene glycol is less and the safety is higher.
【作者单位】：河南大学淮河医院消化内科;
【分类号】：R574.62

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