固醇调节元件结合蛋白2信号通路与非酒精性脂肪性肝病

发布时间：2018-11-15 07:20

【摘要】：非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是以肝细胞内甘油三酯和胆固醇等脂毒性脂肪过度沉积为主要特征的一种临床获得性代谢综合征。最新研究表明,NAFLD向非酒精性脂肪肝炎(NASH)进展时,肝内胆固醇积累可能较甘油三酯更具有细胞毒性风险。固醇调节元件结合蛋白2(sterol regulatory element-binding protein 2,SREBP2)是脂质代谢重要的核转录因子之一,主要调控胆固醇的生物合成和体内平衡。SREBP2及其靶基因调控的胆固醇异常是引起非酒精性脂肪肝病发生发展的重要因素之一。因此,认识SREBP2信号通路中,上下游各因素的表达调控作用与NAFLD发病机制之间关系,就显得非常重要。本文总结了受SREBP2调控表达的靶基因的特点,着重介绍SREBP2调控胆固醇体内合成与平衡的信号通路与NAFLD发病机制之间关系,为研究和指导治疗NAFLD及其代谢性疾病提供新的思路。
[Abstract]:Non-alcoholic fatty liver disease (non-alcoholic fatty liver disease,NAFLD) is a clinically acquired metabolic syndrome characterized by hyperlipidemia of lipids such as triglycerides and cholesterol in hepatocytes. Recent studies have shown that cholesterol accumulation in the liver may be at greater risk of cytotoxicity than triglyceride when NAFLD progresses to non-alcoholic fatty liver disease (NASH). Steroid regulatory element binding protein 2 (sterol regulatory element-binding protein 2 (SREBP2) is one of the important nuclear transcription factors in lipid metabolism. The abnormality of cholesterol regulated by SREBP2 and its target gene is one of the important factors that cause the occurrence and development of non-alcoholic fatty liver disease. Therefore, it is very important to understand the relationship between the expression regulation of upstream and downstream factors and the pathogenesis of NAFLD in SREBP2 signaling pathway. In this paper, the characteristics of target genes regulated by SREBP2 are summarized, and the relationship between the signal pathway of cholesterol synthesis and balance regulated by SREBP2 and the pathogenesis of NAFLD is introduced, which provides a new idea for the study and guidance of the treatment of NAFLD and its metabolic diseases.
【作者单位】：大连大学生命科学与技术学院辽宁省糖脂代谢研究重点实验室;
【基金】：国家自然科学基金(No.81673494)资助~~
【分类号】：R575

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