急性胰腺炎患者在不同时期实施肠内营养对肠源性感染的影响

发布时间：2018-11-15 19:44

【摘要】：目的研究急性胰腺炎(SAP)患者在不同时期实施肠内营养(EN)对肠源性感染的影响,以期为临床治疗提供理论依据。方法选择医院2012年12月-2015年12月诊治68例急性胰腺炎患者,将其分为A、B、C组,A组23例患者在入院第2天开始实施肠内营养,B组23例患者在入院第4天开始实施肠内营养,C组22例患者在入院第6天开始实施肠内营养,比较3组患者各时期生理指标变化、不良反应发生率以及肠源性感染率。结果A组患者入院第5天后白细胞、C-反应蛋白以及内毒素含量明显降低,在第9天时下降至(10.3±1.2)×109/L、(55.0±14.0)mg/L及(0.4±0.2)EU/L,下降程度明显比B和C组少,差异有统计学意义(P0.05);A组患者中有1例出现肠源性感染,感染率为4.4%,B组中有2例出现肠源性感染,感染率为8.7%,C组中有4例出现肠源性感染,感染率为18.2%;3组患者中均有2例出现不良反应,不良反应发生率比较,差异无统计学意义。结论急性胰腺炎患者在入院第2天开始实施肠内营养能够很好的降低炎症反应,对肠源性感染的发生发展起到预防作用,属于一种可靠、高效的治疗方法。
[Abstract]:Objective to study the effect of enteral nutrition (EN) on enterogenous infection in patients with acute pancreatitis (SAP) at different stages in order to provide theoretical basis for clinical treatment. Methods Sixty-eight patients with acute pancreatitis from December 2012 to December 2015 were divided into two groups: group A (n = 23) and group A (n = 23) who received enteral nutrition on the second day of admission. Enteral nutrition was performed in 23 patients in group B and 22 patients in group C on the 4th day after admission. The changes of physiological indexes, the incidence of adverse reactions and the rate of enterogenic infection were compared among the three groups. Results the levels of leukocyte, C-reactive protein and endotoxin in group A were significantly decreased on the 5th day after admission to (10.3 卤1.2) 脳 10 ~ (9) / L, (55.0 卤14.0) mg/L and (0.4 卤0.2) EU/L, on the 9th day. The degree of decrease was significantly lower than that of group B and C (P0.05). One of the patients in group A had enterogenic infection, 2 of group B had enterogenic infection, and 4 of group C had enterogenic infection, and the infection rate was 18.2. There were 2 cases of adverse reactions in the three groups, and there was no significant difference in the incidence of adverse reactions. Conclusion Enteral nutrition in patients with acute pancreatitis on the second day of admission can reduce inflammatory reaction and prevent the occurrence and development of enterogenous infection. It is a reliable and effective treatment method.
【作者单位】：承德市中心医院营养科;河北承德县医院医务科;
【基金】：河北省教育厅自然科学基金资助项目(2012B360216)
【分类号】：R576

【相似文献】