布加综合征患者血清同型半胱氨酸水平与肝纤维化程度的关系

发布时间：2018-11-15 20:39

【摘要】：目的探讨血清同型半胱氨酸(Hcy)水平对于布加综合征(BCS)患者肝纤维化程度的诊断价值。方法收集BCS患者97例及同期健康体检者30例,根据Child-Pugh分级标准将BCS患者分为Child-Pugh A级组(n=49)、Child-Pugh B级组(n=31)、Child-Pugh C级组(n=17)。同时测定血清Hcy及肝纤维化指标(HA、Ⅳ-C、PCⅢ)。结果 BCS患者血清Hcy水平显著高于健康体检者(P0.01),且随着Child-Pugh分级的升高而递增,相邻组间比较差异有统计学意义(P0.01)。BCS患者血清Hcy水平与Child-Pugh得分呈正相关(r=0.663 4,P0.01),Hcy水平与肝纤维化指标(HA、Ⅳ-C、PCⅢ)水平均呈正相关(r=0.465 7、0.460 6、0.530 0,均P0.01)。结论 BCS患者血清Hcy水平显著升高且与患者肝纤维化程度有良好的相关性,检测血清Hcy水平有助于BCS患者肝纤维化程度诊断。
[Abstract]:Objective to investigate the diagnostic value of serum homocysteine (Hcy) level in liver fibrosis in patients with Budd Chiari syndrome (BCS). Methods 97 patients with BCS and 30 healthy controls were divided into Child-Pugh A group (n = 49), Child-Pugh B group (n = 31) and Child-Pugh C group (n = 17) according to Child-Pugh grading criteria. Serum Hcy and liver fibrosis index (HA, 鈪，

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