血小板计数评价溃疡性结肠炎活动度及严重度的Meta分析

发布时间：2018-11-21 17:04

【摘要】：研究目的溃疡性结肠炎是一种病因、发病机制尚未明确的肠道慢性非特异性炎症,具有反复发作、迁延不愈的特点。准确及时地判断疾病的活动度及严重度对于调整治疗方案、减轻患者经济负担以及改善患者预后具有重要意义。本研究通过对溃疡性结肠炎在不同病情分期、不同严重程度时血小板计数的差异进行统计比较与Meta分析,进一步了解血小板计数在溃疡性结肠炎活动度与严重度评价方面的指标效应,明确血小板计数分析在溃疡性结肠炎患者中的临床意义,为临床依据血小板计数判断疾病活动度和严重度提供参考依据。研究方法通过检索Pubmed及CNKI数据库,对截止至2014年12月11日发表的有关血小板计数与溃疡性结肠炎相关性的文献进行筛选。根据纳入和排除标准,提取符合条件的文献中正常对照组、缓解期组及活动期组的例数及血小板均数值,并运用Stata软件进行数据合并及分析。研究结果共检索出英文文献561篇,中文文献335篇,通过筛选最终纳入符合条件的18篇文献。以血小板均数值作为评价指标,两两合并,在正常对照组和缓解期组:n=18,SMD=-0.30,95%CI(-0.50~-0.09);缓解期组和活动期组:n=16,SMD=-0.72,95%CI(-0.95~-0.48);轻度组和中度组:n=5,SMD=-0.81,95%CI(-1.08~-0.54);中度组和重度组:n=5,SMD=-0.85,95%CI(-1.36~-0.34);合并结果均具有统计学意义。研究结论①血小板计数在溃疡性结肠炎患者中较正常人群升高。②血小板计数在溃疡性结肠炎的活动期较缓解期升高,可以作为评价溃疡性结肠炎活动度的指标之一。③血小板计数与溃疡性结肠炎的严重度呈正相关,可作为评价溃疡性结肠炎严重度的指标之一。
[Abstract]:Objective ulcerative colitis is a kind of etiology. The pathogenesis of ulcerative colitis is not clear. It is important to judge the activity and severity of the disease accurately and timely for adjusting the treatment plan, reducing the economic burden of the patients and improving the prognosis of the patients. In this study, the differences of platelet count in different stages and severity of ulcerative colitis were compared and analyzed by Meta. To further understand the effect of platelet count on the evaluation of activity and severity of ulcerative colitis, and to clarify the clinical significance of platelet count analysis in patients with ulcerative colitis. To provide reference for clinical diagnosis of disease activity and severity based on platelet count. Methods by searching the databases of Pubmed and CNKI, the literatures about the correlation between platelet count and ulcerative colitis as of December 11, 2014 were selected. According to the inclusion and exclusion criteria, the cases and platelet values of normal control group, remission group and active group were extracted, and the data were combined and analyzed by Stata software. Results A total of 561 articles in English and 335 articles in Chinese were retrieved. The platelet mean value was used as the evaluation index. In the normal control group and the remission group, the normal control group and the remission stage group: nongy18SMD-0.30 ~ 95 CI (-0.50 ~ -0.09); In the remission stage and active stage group, the CI was 0.95% (-0.95U -0.48), and that in the mild and moderate groups was (-1.08U -0.54). In moderate group and severe group, there was significant difference in CI (-1.36 ~ -0.34) between SMD-0.85 and SMD-0.85, and the combined results were statistically significant. Conclusions\ The platelet count is positively correlated with the severity of ulcerative colitis and can be used as an index to evaluate the severity of ulcerative colitis.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R574.62

【参考文献】