抗幽合剂联合四联疗法治疗慢性胃炎合并幽门螺杆菌阳性患者25例临床观察

发布时间：2018-11-24 14:43

【摘要】：目的评价抗幽合剂联合四联疗法对慢性胃炎合并幽门螺杆菌(Hp)阳性患者Hp根除率的影响。方法将75例慢性胃炎合并Hp阳性患者随机分为对照组、辨证组、抗幽组各25例。对照组给予西药四联疗法(奥美拉唑肠溶胶囊每次20 mg,阿莫西林胶囊每次1g或克拉霉素胶囊每次500 mg,左氧氟沙星片每次200 mg,枸橼酸铋钾冲剂每次220 mg口服,均每日2次);辨证组给予西药四联疗法加中医辨证论治汤剂口服,每日1剂,每日2次;抗幽组给予西药四联疗法加抗幽合剂口服,每日1剂,每日2次。各组均治疗14天。分别于治疗前后评价各组患者主要症状评分、中医脾胃疾病患者报告临床结局(PRO)量表评分,以及血、尿、便常规和肝功能、肾功能等安全性指标,并于停药30天后检测各组患者Hp转阴情况。结果对照组Hp转阴17例、Hp根除率为68.0%,抗幽组为23例、95.8%,辨证组为19例、76.0%,抗幽组与辨证组Hp根除率均高于对照组(P0.01)。治疗后各组患者主要症状积分与PRO量表各症状、维度、总分均较治疗前显著明显降低(P0.05或P0.01),治疗后各组间比较差异无统计学意义(P0.05)。治疗前后各组安全性指标比较差异无统计学意义(P0.05)。结论抗幽合剂联合西药四联疗法能够提高慢性胃炎合并Hp阳性患者的Hp根除率,并能安全有效地改善患者临床症状。
[Abstract]:Objective to evaluate the effect of Kangyou mixture combined with tetralogy on Hp eradication rate in patients with chronic gastritis complicated with Helicobacter pylori (Hp) positive. Methods 75 patients with chronic gastritis combined with Hp positive were randomly divided into control group, syndrome differentiation group and anti-Youyou group. The control group was treated with western medicine tetralogy (omeprazole enteric-coated capsule 20 mg, amoxicillin capsule 1 g / time or clarithromycin capsule 500 mg, levofloxacin tablet 200 mg, bismuth potassium citrate granules for 220 mg). Twice a day); The syndrome differentiation group was given western medicine combined with TCM syndrome differentiation decoction once a day, and the anti-Youyou group was given western medicine quadruple therapy plus anti-you mixture, 1 dose daily, 2 times a day. All groups were treated for 14 days. The main symptoms of each group were evaluated before and after treatment, the (PRO) score of clinical outcome was reported by TCM patients with spleen and stomach disease, and the safety indexes such as blood, urine, stool routine, liver function, renal function, etc. After 30 days of withdrawal, the Hp of the patients in each group was detected. Results in the control group, 17 cases of Hp turned negative, the eradication rate of Hp was 68.0, the anti-Youyou group was 23 cases, 95.8 cases, and the syndrome differentiation group was 19 cases, 76.0%. The eradication rate of Hp in the anti-Youyou group and syndrome differentiation group was higher than that in the control group (P0.01). After treatment, the main symptom score and PRO scale symptoms, dimensions, total scores were significantly lower than before treatment (P0.05 or P0.01), there was no significant difference between groups after treatment (P0.05). Before and after treatment, there was no significant difference in safety indexes between groups (P0.05). Conclusion the combination of Kangyou mixture and western medicine can improve the Hp eradication rate of patients with chronic gastritis and Hp positive patients, and can improve the clinical symptoms of patients safely and effectively.
【作者单位】：辽宁中医药大学;辽宁中医药大学附属医院;
【基金】：国家科技重大专项(2010ZX09401-304) 2012年辽宁省中医药临床学(专科)能力建设项目(2012-lnzyxzk-03)
【分类号】：R573.3

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