血清免疫球蛋白对非酒精性脂肪性肝病肝纤维化的诊断价值分析

发布时间：2018-11-25 12:07

【摘要】：目的探讨血清免疫球蛋白对诊断非酒精性脂肪性肝病(NAFLD)患者肝纤维化的价值。方法以泰州市人民医院及苏州大学附属第一医院2011年1月至2014年3月间进行肝组织活检确诊的98例NAFLD患者为研究对象,回顾性分析肝组织病理学分期及血清免疫球蛋白、生化、体重指数(BMI)等指标,用受试者操作特征(ROC)曲线等方法评估其诊断价值。结果 98例患者中男性65例,病理肝纤维化分期提示显著纤维化(S3~S4)38例。显著纤维化组的年龄、BMI、ALT、ALB、血小板计数、血清Ig A与对照组比较差异有统计学意义(P0.05);Ig A、FIB-4、APRI对肝脏显著纤维化都具有一定诊断价值,三者曲线下面积分别为0.857、0.783、0.782。Ig A阳性预测值达85%。结论血清Ig A可作为诊断肝纤维化进展的指标之一。
[Abstract]:Objective to investigate the value of serum immunoglobulin in the diagnosis of hepatic fibrosis in (NAFLD) patients with non-alcoholic fatty liver disease. Methods 98 patients with NAFLD confirmed by liver biopsy from January 2011 to March 2014 in Taizhou people's Hospital and the first affiliated Hospital of Suzhou University were selected as study subjects. The pathological stages of liver and serum immunoglobulin and biochemistry were analyzed retrospectively. Body mass index (BMI) and (ROC) curve were used to evaluate the diagnostic value. Results among 98 cases, 65 cases were male, 38 cases showed marked fibrosis (S3~S4) by pathological hepatic fibrosis stage. There were significant differences in age, BMI,ALT,ALB, platelet count and serum Ig A between the significant fibrosis group and the control group (P0.05). The area under the three curves was 0.8570.783n0.782IgaA positive predictive value was 852.The positive predictive value of FIB-4APRI for hepatic fibrosis was 85% and the area under the three curves was 0.85 7 / 0.783 / 0.782.The positive predictive value of FIB-4 / APRI was 85%, respectively. Conclusion Serum Ig A can be used as an index to diagnose the progression of hepatic fibrosis.
【作者单位】：苏州大学附属第一医院感染科;泰州市人民医院肝病科;
【基金】：国家“十二五”科技重大专项子课题(2012ZX-10002004) 天晴肝病研究基金(CFHPC20132110) 江苏干部保健科研课题(BJ14032)
【分类号】：R575.5

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