幽门螺杆菌感染的家庭聚集现象
发布时间：2018-12-11 22:05
【摘要】：幽门螺杆菌(H.pylori)是一种导致全球近50%人群感染的微需氧菌,是慢性胃炎、消化性溃疡和胃粘膜相关淋巴组织淋巴瘤的主要致病因子,并且与胃癌的发生密切相关,1994年国际癌症研究机构将其列为Ⅰ类致癌因子[1]。根除H.pylori可有效地防治其相关性疾病尤其是胃癌的发生。现已明确H.pylori相关性疾病是一种感染性疾病,它可在人与人之间传播[2-4],家庭是H.pylori最易传播的场所,大量研究提示H.pylori感染存在家庭聚集性,与H.pylori根除治疗失败、复发和再感染密切相关,并且在反复治疗复发与再感染病例过程中,会诱导耐药菌株的产生,增加根除难度。本文就H.pylori感染家庭聚集现象、其产生机制及如何防治等进行一综述。
[Abstract]:Helicobacter pylori (H.pylori) is a microaerobic bacterium that causes infection in nearly 50% of the world's population. It is the main pathogenic factor of chronic gastritis, peptic ulcer and gastric mucosa-associated lymphoid tissue lymphoma, and is closely related to the occurrence of gastric cancer. In 1994, the International Agency for Research on Cancer (IARC) classified it as a class I carcinogen [1]. Eradication of H.pylori can effectively prevent and treat its associated diseases, especially gastric cancer. It has been established that H.pylori related disease is an infectious disease that can be transmitted from person to person [2-4]. Family is the most easily transmitted site of H.pylori. A large number of studies suggest that H.pylori infection has family aggregation. It is closely related to the failure of H.pylori eradication treatment, recurrence and re-infection, and in the process of repeated treatment of recurrent and re-infection cases, it will induce the production of drug-resistant strains and increase the difficulty of eradication. This article reviews the phenomenon of family aggregation of H.pylori infection, its producing mechanism and how to prevent and cure it.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R573
本文编号：2373303
[Abstract]:Helicobacter pylori (H.pylori) is a microaerobic bacterium that causes infection in nearly 50% of the world's population. It is the main pathogenic factor of chronic gastritis, peptic ulcer and gastric mucosa-associated lymphoid tissue lymphoma, and is closely related to the occurrence of gastric cancer. In 1994, the International Agency for Research on Cancer (IARC) classified it as a class I carcinogen [1]. Eradication of H.pylori can effectively prevent and treat its associated diseases, especially gastric cancer. It has been established that H.pylori related disease is an infectious disease that can be transmitted from person to person [2-4]. Family is the most easily transmitted site of H.pylori. A large number of studies suggest that H.pylori infection has family aggregation. It is closely related to the failure of H.pylori eradication treatment, recurrence and re-infection, and in the process of repeated treatment of recurrent and re-infection cases, it will induce the production of drug-resistant strains and increase the difficulty of eradication. This article reviews the phenomenon of family aggregation of H.pylori infection, its producing mechanism and how to prevent and cure it.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R573
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