肝损伤患者血清肝活素水平测定的临床意义

发布时间：2018-12-27 09:16

【摘要】：目的探究肝活素(HPS)在阻塞性黄疸所致肝损伤的诊断以及慢性肝病肝功能评估中的作用。方法 ELISA法检测60例阻塞性黄疸患者、68例慢性肝病患者及30例健康体检者血清HPS水平。分析肝损伤患者与正常人血清HPS水平有无差异;对阻塞性黄疸患者血清HPS和丙氨酸氨基转移酶(ALT)进行相关性分析;绘制受试者工作特征曲线,观察HPS对阻塞性黄疸所致肝损伤的诊断价值;分析慢性肝病患者HPS与Child-Pugh分级(CPC)以及肝衰竭之间的关系。结果阻塞性黄疸和慢性肝病患者血清HPS水平均显著高于对照组(P0.01)。阻塞性黄疸患者血清中HPS与ALT呈正相关性(rs=0.914,P0.01);HPS在阻塞性黄疸肝损伤诊断中的曲线下面积达到0.938,最佳节点是141.87μg/L;慢性肝病中非衰竭者Child A、Child B、Child C与慢加急性肝衰竭、慢性肝衰竭5组之间两两比较,非肝衰竭组中,随着CPC升高,HPS水平也逐渐升高(P0.05),两组肝衰竭血清HPS水平均高于非衰竭各组(P0.05),两组肝衰竭之间HPS水平差异无统计学意义。结论血清HPS水平测定能够对阻塞性黄疸患者有无肝损伤作出诊断,也能够辅助CPC评估慢性肝病患者肝功能。
[Abstract]:Objective to investigate the role of activin (HPS) in the diagnosis of liver injury caused by obstructive jaundice and the assessment of liver function in chronic liver disease. Methods Serum HPS levels were measured by ELISA in 60 patients with obstructive jaundice, 68 patients with chronic liver disease and 30 healthy controls. To analyze the difference of serum HPS levels between patients with liver injury and normal subjects, and to analyze the correlation between serum HPS and alanine aminotransferase (ALT) in patients with obstructive jaundice. The diagnostic value of HPS in liver injury caused by obstructive jaundice was observed by drawing the operating characteristic curve of the subjects, and the relationship between HPS, Child-Pugh grade (CPC) and liver failure in patients with chronic liver disease was analyzed. Results Serum HPS levels in patients with obstructive jaundice and chronic liver disease were significantly higher than those in control group (P0.01). There was a positive correlation between serum HPS and ALT in patients with obstructive jaundice (the area under the curve of rs=0.914,P0.01); HPS in the diagnosis of obstructive jaundice liver injury was 0.938, the best node was 141.87 渭 g / L). Compared with chronic liver failure group and chronic liver failure group, HPS level increased gradually with the increase of CPC in non-hepatic failure group (P0.05), and the level of HPS in non-hepatic failure group was higher than that in chronic liver failure group (P0.05), and the level of HPS in non-hepatic failure group was higher than that in chronic liver failure group (P0.05). The level of serum HPS in the two groups was higher than that in the non-failure group (P0.05). There was no significant difference in HPS level between the two groups. Conclusion Serum HPS level can be used to diagnose liver injury in patients with obstructive jaundice and to evaluate liver function in patients with chronic liver disease by CPC.
【作者单位】：安徽医科大学第一附属医院肝胆胰外科一病区;
【基金】：安徽省高校省级自然科学研究项目(编号:KJ2014A117)
【分类号】：R575

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