急性胆系疾病肌钙蛋白升高的临床研究

发布时间：2018-12-30 10:41

【摘要】：目的:本研究拟探讨引起急性胆系疾病患者肌钙蛋白升高的临床相关因素,进一步提高对急性胆系疾病患者肌钙蛋白升高的临床认识。方法:连续收集115例临床上确诊的急性胆系疾病患者,根据肌钙蛋白检测结果分为肌钙蛋白升高组18例,肌钙蛋白正常组97例,记录纳入样本的临床资料,包括性别、年龄、既往有无冠心病及其等危症、急性胆系疾病病情严重程度、胆囊扩张或胆管扩张等,采用Logistic回归分析急性胆系疾病患者合并肌钙蛋白升高的相关危险因素。结果:在115例确诊急性胆系疾病的患者中,18例患者肌钙蛋白升高,发生率为15.65%,通过单因素分析发现急性胆系疾病病情严重程度,C反应蛋白(CRP)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)、胆管扩张与急性胆系疾病肌钙蛋白升高差异有统计学意义(P0.05),通过多因素Logistic回归分析显示C反应蛋白(OR=1.052;90%CI,1.024~1.082),ALT(OR=1.006;90%CI,1.002~1.011),疾病严重程度(OR=4.681;90%CI,1.132~19.361)是急性胆系疾病患者肌钙蛋白升高的独立危险因素。α入=0.05,α出=0.10,P0.1有统计学意义。结论:C反应蛋白(CRP)、谷丙转氨酶(ALT)、疾病病情严重程度是急性胆系疾病患者肌钙蛋白升高的独立危险因素。
[Abstract]:Objective: to investigate the clinical factors related to the elevation of cardiac troponin in patients with acute biliary diseases and to improve the clinical understanding of the elevation of troponin in patients with acute biliary diseases. Methods: 115 patients with acute biliary diseases were collected and divided into 18 patients with elevated troponin and 97 patients with normal cardiac troponin according to the results of cardiac troponin test. The clinical data including sex and age were recorded. Logistic regression analysis was used to analyze the risk factors associated with elevated cardiac troponin in patients with acute biliary diseases such as coronary heart disease (CHD) and its isotherapies, severity of acute biliary diseases, gallbladder dilatation or bile duct dilatation. Results: of the 115 patients with acute biliary diseases, 18 had elevated troponin (15.65%). The severity of acute biliary diseases and C-reactive protein (CRP),) were found by univariate analysis. Glutamic pyruvic transaminase (ALT),) and total bilirubin (TBIL), (AST),) were significantly higher than those in acute biliary diseases (P0.05). Identification of C-reactive protein (OR=1.052;) by multivariate Logistic regression analysis 90CIN 1.024 1.082), ALT (OR=1.006;90%CI,1.002~1.011), severity of disease (OR=4.681;) 90CII 1.132 ~ 19.361) is an independent risk factor for the elevation of cardiac troponin in patients with acute biliary diseases, 伪 -input = 0.05, 伪 -output = 0.10p _ (0.1). Conclusion: the severity of C-reactive protein (CRP), glutamate-alanine aminotransferase (ALT),) disease is an independent risk factor for the elevation of troponin in patients with acute biliary diseases.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R575.6

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