营养干预对重度溃疡性结肠炎病人的治疗价值

发布时间：2019-02-09 15:11

【摘要】：目的:探讨营养干预对重度溃疡性结肠炎(UC)的治疗价值。方法:回顾性分析36例重度UC病人资料,其中20例病人进行了肠外营养(PN)或肠内营养(EN)治疗为观察组,其余16例为对照组。比较两组病人住院时间以及治疗前后的营养指标、血清内毒素、IL-4和外周血CD4+CD25+调节性T细胞(CD4+CD25+Treg)水平。结果:给予营养干预的观察组病人住院时间较对照组明显缩短(P0.05);治疗后的血清总蛋白(TP)、清蛋白(ALB)、前清蛋白(PA)、转铁蛋白(TF)水平较治疗前有明显增高,且改善程度显著高于对照组(P0.05);治疗后的血清内毒素水平亦较治疗前明显降低;IL-4及外周血CD4+CD25+Treg水平明显增加,与对照组比,差异有统计学意义(P0.05)。在营养支持中腹泻的发生率为20%,占所有不良反应的66.7%。结论:营养支持治疗可显著改善重度UC病人的临床病情及营养状况,对UC病人的免疫调节功能也有一定影响。
[Abstract]:Objective: to explore the value of nutritional intervention in the treatment of severe ulcerative colitis (UC). Methods: the data of 36 patients with severe UC were retrospectively analyzed. 20 cases were treated with parenteral nutrition (PN) or enteral nutrition (EN) as observation group and the other 16 cases as control group. The duration of hospitalization, nutritional parameters, serum endotoxin, IL-4 and peripheral blood CD4 CD25 regulatory T cell (CD4 CD25 Treg) levels were compared between the two groups. Results: the hospitalization time of the patients in the observation group was significantly shorter than that in the control group (P0.05). The level of serum total protein (TP), albumin (ALB), prealbumin (PA), transferrin (TF) was significantly higher than that before treatment and the improvement was significantly higher than that of the control group (P0.05). After treatment, the level of serum endotoxin was also significantly lower than that before treatment, IL-4 and peripheral blood CD4 CD25 Treg levels were significantly increased, compared with the control group, the difference was statistically significant (P0.05). The incidence of diarrhea in nutritional support was 20, accounting for 66.7% of all adverse reactions. Conclusion: nutritional support therapy can significantly improve the clinical condition and nutritional status of patients with severe UC, and also affect the immunomodulation function of UC patients.
【作者单位】：广东省医学科学院暨广东省人民医院消化内科;
【分类号】：R574.62

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