多烯磷脂酰胆碱联合维生素E治疗非酒精性脂肪肝的疗效及安全性评价

发布时间：2019-03-05 18:42

【摘要】：目的评价多烯磷脂酰胆碱(PPC)联合维生素E治疗非酒精性脂肪肝(NAFLD)的临床疗效及安全性。方法入选非酒精性脂肪肝患者66例随机分为试验组32例和对照组34例。试验组静脉滴注PPC 465 mg,qd,口服维生素E50 mg,tid,1个月后改为PPC 232.5 mg,维生素E 50 mg,继续用药2个月。对照组静脉滴注葡萄糖醛酸内酯0.6 g与维生素C 1000 mg,qd,1个月后改为葡萄糖醛酸内酯0.2 g与维生素C 300 mg,tid,继续用药2个月。比较2组患者治疗前后临床有效率、肝功能(谷草转氨酶、谷丙转氨酶、γ谷氨酰转移酶)及血脂(三酰甘油和总胆固醇)、B超检查结果及不良反应发生率。结果试验组总有效率87.5%,显著高于对照组的47.1%(P0.05)。治疗后,2组谷草转氨酶、谷丙转氨酶、γ谷氨酰转移酶及三酰甘油和总胆固醇均较治疗前显著降低(P0.05),且试验组上述指标均低于对照组(P0.05)。2组患者不良反应发生率差异无统计学意义(P0.05)。结论 PPC联合维生素E治疗非酒精性脂肪肝安全、有效。
[Abstract]:Objective to evaluate the clinical efficacy and safety of polyene phosphatidylcholine (PPC) combined with vitamin E in the treatment of nonalcoholic fatty liver (NAFLD). Methods 66 patients with nonalcoholic fatty liver were randomly divided into test group (n = 32) and control group (n = 34). In the experimental group, PPC 465 mg,qd, was administered orally with vitamin E 50 mg,tid,1 for 2 months and then changed to PPC 232.5 mg, vitamin E 50 mg, for 2 months. The control group was given glucuronolactone 0. 6g and vitamin C 1000 mg,qd,1 for 2 months, then replaced with glucuronolactone 0. 2 g and vitamin C 300 mg,tid, for 2 months. The clinical effective rate, liver function (glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, 纬 glutamyltransferase), blood lipid (triacylglycerol and total cholesterol), B ultrasound examination results and incidence of adverse reactions were compared between the two groups before and after treatment. Results the total effective rate of the experimental group was 87.5%, which was significantly higher than that of the control group (47.1%, P0.05). After treatment, the levels of glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase, 纬-glutamyltransferase, triacylglycerol and total cholesterol in the two groups were significantly lower than those before treatment (P0.05). The above indexes in the test group were lower than those in the control group (P0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P0.05). Conclusion PPC combined with vitamin E is safe and effective in the treatment of nonalcoholic fatty liver.
【作者单位】：宁波市第一医院消化科;
【基金】：浙江省自然科学基金资助项目(LY13H030012)
【分类号】：R575.5

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