海南省2013年乙型病毒性肝炎高流行区育龄妇女血清学调查

发布时间：2019-03-06 10:35

【摘要】：目的了解2013年海南省乙型病毒性肝炎(乙肝)高流行区育龄妇女乙肝病毒(HBV)感染情况,评估乙肝疫苗(HepB)接种效果。方法采用分层随机抽样方法在海南省3个乙肝高流行县(区、市),抽取15-49岁女性进行调查并采集血清标本;检测血清HBV表面抗原(HBsAg)、抗HBsAg抗体(Anti-HBs)、抗HBV核心抗原抗体(AntiHBc)、HBV e抗原(HBe Ag)、抗HBe Ag抗体(Anti-HBe)、HBV-DNA载量和HBV基因型,进行描述性分析。结果育龄妇女的HBsAg、Anti-HBs、Anti-HBc阳性率分别为8.88%(151/1 701)、55.50%(944/1 701)、15.23%(259/1 701);HBsAg阳性者中HBe Ag、Anti-HBe、HBV-DNA载量阳性率分别为32.45%(49/151)、65.56%(99/151)、47.68%(72/151);HBV-DNA载量阳性者中B、C、B+C基因型分别占25.00%(18/72)、72.22%(52/72)、2.78%(2/72)。育龄妇女的年龄别HBsAg阳性率在7.04%(40-49岁)-10.65%(20-29岁)之间(χ~2=5.27,Р0.05);有、无、不详HepB免疫史人群HBsAg阳性率分别为6.43%、12.09%、8.65%(χ~2=9.77,Р=0.008);职业别人群HBsAg阳性率在2.53%(学生)-15.04%(公共场所人员)之间(χ~2=11.60,Р=0.007)。结论海南省2013年乙肝高流行区育龄妇女的HBV感染率处于较高水平,以C基因型为主;需继续加强HepB预防接种工作,落实HBV母婴传播阻断干预措施。
[Abstract]:Objective to investigate the infection of hepatitis B virus (HBV) in women of childbearing age in Hainan province in 2013, and to evaluate the effect of hepatitis B vaccine (HepB) vaccination. Methods A stratified random sampling method was used in 3 counties (districts and cities) with high prevalence of hepatitis B in Hainan Province. 15-49-year-old women were selected for investigation and serum samples were collected. The serum HBV surface antigen (HBsAg), anti-HBsAg antibody (Anti-HBs), anti-HBV core antigen (AntiHBc), HBV e antigen (HBe Ag), anti-HBe Ag antibody (Anti-HBe), HBV-DNA load and HBV genotype were detected for descriptive analysis. Results the positive rates of HBsAg,Anti-HBs,Anti-HBc in women of childbearing age were 8.88% (151 / 1701), 55.50% (944 / 1701) and 15.23% (259 / 1701), respectively. The positive rates of HBe Ag,Anti-HBe,HBV-DNA load in HBsAg positive patients were 32.45% (49 / 151), 65.56% (99 / 151) and 47.68% (72 / 151), respectively. B, C and B C genotypes accounted for 25.00% (18 / 72), 72.22% (52 / 72) and 2.78% (2 / 72) respectively in positive HBV-DNA carriers. The positive rate of age-specific HBsAg in women of childbearing age ranged from 7.04% (40 to 49 years) to 10.65% (20 years old) (蠂 ~ 2 / 5.27, ~ (0.05). The positive rates of HBsAg were 6.43%, 12.09%, 8.65% (蠂 ~ 2, 9.77,), respectively (蠂 ~ 2, 9.77, = 0.008) in the population with unknown HepB immunization history. The positive rate of HBsAg in occupational group ranged from 2.53% (students) to 15.04% (public workers) (蠂 ~ 2 / 11.60, / = 0.007). Conclusion the infection rate of HBV in women of childbearing age in the high prevalence area of hepatitis B in 2013 in Hainan Province is at a high level, mainly with genotype C, and it is necessary to continue to strengthen the work of HepB vaccination and implement the intervention measures of blocking mother-to-child transmission of HBV.
【作者单位】：海南省疾病预防控制中心;
【基金】：“十二五”国家科技重大专项-艾滋病和病毒性肝炎等重大传染病防治(编号2012ZX10002001)
【分类号】：R512.62

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