复方黄柏液联合化学药治疗溃疡性结肠炎的Meta分析

发布时间：2019-03-17 09:43

【摘要】：目的:系统评价复方黄柏液联合化学药治疗溃疡性结肠炎(UC)的疗效和安全性,为临床提供循证参考。方法:计算机检索中国生物医学文献数据库(CBM)、万方数据库、中文科技期刊全文数据库(VIP)、相关期刊论文(CJFD)、PubMed、EMBase和Cochrane图书馆,收集复方黄柏液联合化学药(试验组)对比单纯化学药(对照组)治疗UC的随机对照试验(RCT),筛选文献、提取资料并按照Cochrane reviewer’s handbook 5.1.0评价质量后,采用RevMan 5.3统计软件进行Meta分析。结果:共纳入8项RCT,合计737例患者。Meta分析结果显示,试验组患者总有效率显著高于对照组,差异有统计学意义[OR=4.69,95%CI(3.00,7.34),P0.001];两组患者不良反应发生率比较,差异无统计学意义[OR=0.94,95%CI(0.48,1.84),P=0.86]。结论:复方黄柏液联合化学药治疗UC疗效优于单纯化学药,但两者安全性相当。
[Abstract]:Aim: to evaluate the efficacy and safety of compound Huangbai liquid combined with chemotherapy in the treatment of ulcerative colitis (UC), and to provide evidence-based reference for clinical use. Methods: Chinese biomedical literature database (CBM), Wanfang database, Chinese sci-tech journal full-text database (VIP), Chinese journal full-text database (CJFD), PubMed,EMBase and Cochrane library were searched by computer. A randomized controlled trial (RCT),) of compound Huangbai liquid combined with chemical drugs (control group) for the treatment of UC was collected. After extracting the data and evaluating the quality according to Cochrane reviewer's handbook 5.1.0, the results of the randomized controlled trial were compared with those of the control group (control group). Meta analysis was carried out with RevMan 5.3 statistical software. Results: the total effective rate of the test group was significantly higher than that of the control group [OR=4.69,95%CI (3.00,7.34), P0.001]. Meta-analysis showed that the total effective rate of the test group was significantly higher than that of the control group [OR=4.69,95%CI (3.00,7.34), P0.001]; There was no significant difference in the incidence of adverse reactions between the two groups [OR=0.94,95%CI (0.48,1.84), P = 0.86]. Conclusion: the curative effect of compound Huangbai liquid combined with chemotherapy on UC is better than that of simple chemical medicine, but the safety of the two drugs is the same.
【作者单位】：广州中医药大学第一附属医院;广州中医药大学基础医学院;
【基金】：国家自然科学基金资助项目(No.81403296)
【分类号】：R574.62

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