10年间溃疡性结肠炎住院患者临床特征和治疗方式演变

发布时间：2019-04-10 17:08

【摘要】：目的探讨过去10年间溃疡性结肠炎(UC)住院患者临床特征和治疗方式的演变。方法通过航天中心医院病案管理系统收集2003年1月—2012年12月住院诊断为UC患者的临床资料,记录患者一般资料、临床特征(临床类型、疾病分期、严重程度及病变范围)、治疗方式。比较前5年(2003—2007年)和后5年(2008—2012年)患者一般资料、临床特征和治疗方式的演变。结果共纳入115例患者,发病高峰年龄段分别为20~29岁(17例,占14.8%)及50~69岁(52例,占45.2%)。前5年纳入患者49例,后5年纳入患者66例,前、后5年患者病程比较,差异有统计学意义(Z=-2.522,P0.05)。115例患者临床类型以初发型为主,占55.6%(64/115);疾病分期多处于活动期,占93.9%(108/115);严重程度以轻、中度为主,占81.5%(88/108);病变范围以广泛结肠型为主,占51.3%(59/115)。115例患者均行内科药物治疗,其中应用氨基水杨酸制剂者97例(84.3%),包括单用水杨酸偶氮磺胺吡啶(SASP)者33例(28.7%),单用5-氨基水杨酸(5-ASA)者55例(47.8%),SASP+5-ASA者9例(7.8%);局部保留灌肠者80例(69.6%)。前、后5年患者微生态制剂、止泻药使用率和局部保留灌肠治疗率比较,差异有统计学意义(χ2=4.000、3.997、4.054,P0.05)。结论 20~29岁及50~69岁是UC的发病高峰年龄段,初发型、轻中度活动期、广泛结肠型多见,病变范围呈扩大化,氨基水杨酸制剂仍是治疗UC的主要药物,微生态制剂、局部保留灌肠逐渐应用于治疗。
[Abstract]:Objective to investigate the clinical characteristics and treatment of ulcerative colitis (UC) in (UC) patients in the past 10 years. Methods the clinical data of patients diagnosed as UC from January 2003 to December 2012 were collected through the Medical record Management system of Space Center Hospital. The general data and clinical characteristics (clinical types, disease stages, severity and range of lesions) of the patients were recorded. Treatment. To compare the evolution of general data, clinical features and treatment methods between the first 5 years (2003-2007) and the latter 5 years (2008-2012). Results 115 patients were enrolled. The peak age of onset was 20 years old (17 cases, 14.8%) and 50 years old (52 cases, 45.2%). 49 cases were included in the first 5 years, 66 cases were included in the next 5 years, and there was a significant difference in the course of disease between the first 5 years and the next 5 years (Z = 2.522, P0.05). The clinical types of 115 patients were mainly primary type. 55.6% (64 / 115); Most of the patients were in active stage, accounting for 93.9% (108 / 115), mild and moderate severity (81.5%, 88 / 108), and mild to moderate severity (81.5%, 88 / 108). 51.3% (59 / 115) of the 115 patients were treated with internal medicine, of which 97 (84.3%) were treated with aminosalicylic acid, and 51.3% (51.3%) were treated with aminosalicylic acid. 33 cases (28.7%) were treated with sulfasalazine salicylate alone, 55 cases (47.8%), SASP 5-ASA) were treated with 5-aminosalicylic acid (5-ASA) alone, 9 cases (7.8%) were treated with 5-aminosalicylic acid (5-ASA) alone. Local retention enema was found in 80 cases (69.6%). Before and after 5 years, the usage rate of antidiarrheal agents and local retention enema treatment rate were significantly different (蠂 2 4 000, 3 997 7, 4 054 4, P0.05). Conclusion Twenty-nine and fifty-nine years old and 50 ~ 69 years old are the peak age of the onset of UC, initial onset, mild to moderate active stage, extensive colon type, enlargement of lesion range, aminosalicylic acid preparation is still the main drug for treatment of UC, and microecological preparation. Local retention enema is gradually applied to the treatment.
【作者单位】：航天中心医院;北京大学航天临床医学院消化科;武汉市普仁医院消化科;
【分类号】：R574.62

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