木瓜三萜片与奥美拉唑胶囊联用治疗非甾体抗炎药致上消化道出血临床研究
发布时间：2019-04-20 09:19
【摘要】：目的:观察木瓜三萜片与奥美拉唑胶囊联用治疗非甾体抗炎药致上消化道出血的疗效与安全性及其对胃黏膜攻击因子(ICAM-1和PAF)和防御因子(COX-1、PGE2、EGF和TFF1)水平的影响。方法:将124例非甾体抗炎药致上消化道出血患者完全随机分成2组:对照组62例、治疗组62例。对照组单用奥美拉唑治疗,治疗组采用木瓜三萜片联合奥美拉唑治疗,2组疗程均为4周。观察2组治疗效果及安全性,治疗前后取静脉血采用ELISA试剂盒检测血清中ICAM-1、PAF和COX-1、PGE2、EGF、TFF1水平的变化。结果:治疗后,治疗组症状积分(腹胀、腹痛、反酸、嗳气等)明显低于对照组,总有效率(95.16%)明显高于对照组(79.03%);治疗前两组血清中ICAM-1、PAF和COX-1、PGE2、EGF、TFF1水平没有差异,分别用相应的药物治疗后,对照组弱有改善,但是与木瓜三萜联用后有显著改善,未见明显不良反应,与对照组比较具有显著性差异。结论:木瓜三萜片与奥美拉唑胶囊联用治疗非甾体抗炎药引起的上消化道出血疗效更好,无明显不良反应,值得临床推广应用。
[Abstract]:Objective: to observe the efficacy and safety of papaya triterpenoid tablets combined with omeprazole capsules in the treatment of upper gastrointestinal bleeding induced by non-steroidal anti-inflammatory drugs (NSAIDs), and to evaluate the efficacy and safety of the combination of triterpene tablets and omeprazole capsules in the treatment of upper gastrointestinal The influence of EGF and TFF1 levels. Methods: 124 patients with upper gastrointestinal bleeding caused by NSAIDs were randomly divided into two groups: control group (n = 62) and treatment group (n = 62). The control group was treated with omeprazole alone, the treatment group was treated with papaya triterpenoid tablets combined with omeprazole, the course of treatment in both groups was 4 weeks. The efficacy and safety of the two groups were observed. The levels of ICAM-1,PAF and COX-1,PGE2,EGF,TFF1 in serum were measured by ELISA kit before and after treatment. Results: after treatment, the symptom scores (abdominal distension, abdominal pain, acid regurgitation, belching, etc.) in the treatment group were significantly lower than those in the control group, and the total effective rate (95.16%) was significantly higher than that in the control group (79.03%). There was no difference in serum levels of ICAM-1,PAF and COX-1,PGE2,EGF,TFF1 between the two groups before treatment. After treatment with the corresponding drugs, the control group was weakly improved, but there was significant improvement in combination with papaya triterpene, and no obvious adverse reactions were observed. Compared with the control group, there was significant difference. Conclusion: the combination of papaya triterpenoid tablet and omeprazole capsule is more effective in the treatment of upper gastrointestinal bleeding caused by non-steroidal anti-inflammatory drugs and has no obvious adverse reaction. It is worth popularizing and applying in clinical practice.
【作者单位】： 三峡大学生物与制药学院;三峡大学中医临床医学院&宜昌市中医医院;三峡大学仁和医院;三峡大学医学院;
【基金】：湖北省民间药物工程研究中心开放基金(2015ZY007) 三峡大学生物与制药学院预研基金(No.Hy1402)
【分类号】：R57
，
本文编号：2461479
[Abstract]:Objective: to observe the efficacy and safety of papaya triterpenoid tablets combined with omeprazole capsules in the treatment of upper gastrointestinal bleeding induced by non-steroidal anti-inflammatory drugs (NSAIDs), and to evaluate the efficacy and safety of the combination of triterpene tablets and omeprazole capsules in the treatment of upper gastrointestinal The influence of EGF and TFF1 levels. Methods: 124 patients with upper gastrointestinal bleeding caused by NSAIDs were randomly divided into two groups: control group (n = 62) and treatment group (n = 62). The control group was treated with omeprazole alone, the treatment group was treated with papaya triterpenoid tablets combined with omeprazole, the course of treatment in both groups was 4 weeks. The efficacy and safety of the two groups were observed. The levels of ICAM-1,PAF and COX-1,PGE2,EGF,TFF1 in serum were measured by ELISA kit before and after treatment. Results: after treatment, the symptom scores (abdominal distension, abdominal pain, acid regurgitation, belching, etc.) in the treatment group were significantly lower than those in the control group, and the total effective rate (95.16%) was significantly higher than that in the control group (79.03%). There was no difference in serum levels of ICAM-1,PAF and COX-1,PGE2,EGF,TFF1 between the two groups before treatment. After treatment with the corresponding drugs, the control group was weakly improved, but there was significant improvement in combination with papaya triterpene, and no obvious adverse reactions were observed. Compared with the control group, there was significant difference. Conclusion: the combination of papaya triterpenoid tablet and omeprazole capsule is more effective in the treatment of upper gastrointestinal bleeding caused by non-steroidal anti-inflammatory drugs and has no obvious adverse reaction. It is worth popularizing and applying in clinical practice.
【作者单位】： 三峡大学生物与制药学院;三峡大学中医临床医学院&宜昌市中医医院;三峡大学仁和医院;三峡大学医学院;
【基金】：湖北省民间药物工程研究中心开放基金(2015ZY007) 三峡大学生物与制药学院预研基金(No.Hy1402)
【分类号】：R57
，
本文编号：2461479
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